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Tefm transcription elongation factor, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 287554, updated on 2-Nov-2024

Summary

Official Symbol
Tefmprovided by RGD
Official Full Name
transcription elongation factor, mitochondrialprovided by RGD
Primary source
RGD:1306595
See related
EnsemblRapid:ENSRNOG00000004000 AllianceGenome:RGD:1306595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306595
Summary
Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription and oxidative phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 125.7), Kidney (RPKM 94.1) and 9 other tissues See more
Orthologs
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Genomic context

See Tefm in Genome Data Viewer
Location:
10q25
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65617547..65622042, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65119657..65124233, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67476006..67478830, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 3 Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene phosphoglycerate mutase 1, pseudogene 3 Neighboring gene small nucleolar RNA SNORA43

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC112833

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA polymerase processivity factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase processivity factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA polymerase processivity factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT enables crossover junction DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NOT involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in oxidative phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription elongation by mitochondrial RNA polymerase IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription elongation factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025626.1NP_001020797.1  transcription elongation factor, mitochondrial

    See identical proteins and their annotated locations for NP_001020797.1

    Status: VALIDATED

    Source sequence(s)
    BC098792
    UniProtKB/Swiss-Prot
    Q4KM51
    UniProtKB/TrEMBL
    R9PXS3
    Related
    ENSRNOP00000070690.3, ENSRNOT00000090278.3
    Conserved Domains (1) summary
    cl22429
    Location:81129
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65617547..65622042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)