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Septin4 septin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287606, updated on 2-Nov-2024

Summary

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Official Symbol
Septin4provided by RGD
Official Full Name
septin 4provided by RGD
Primary source
RGD:1308781
See related
EnsemblRapid:ENSRNOG00000007367 AllianceGenome:RGD:1308781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sept4; EG3RVC; Pnutl2; EG3-1RVC; hCDCREL-2
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including flagellated sperm motility; hematopoietic stem cell homeostasis; and negative regulation of stem cell proliferation. Predicted to act upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Predicted to be located in several cellular components, including axon terminus; perikaryon; and sperm flagellum. Predicted to be part of septin complex. Predicted to be active in several cellular components, including cytoskeleton; dopaminergic synapse; and sperm annulus. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 420.6), Lung (RPKM 367.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Septin4 in Genome Data Viewer
Location:
10q26
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72863969..72888018)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72366729..72390764)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74860068..74884196)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134480848 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dissection of a human septin: definition and characterization of distinct domains within human SEPT4. Garcia W, et al. Biochemistry, 2006 Nov 21. PMID 17105210
  2. Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. Ono R, et al. Mol Cell Biol, 2005 Dec. PMID 16314519, Free PMC Article
  3. The Sept4 septin locus is required for sperm terminal differentiation in mice. Kissel H, et al. Dev Cell, 2005 Mar. PMID 15737931
  4. Differential gene expressions in the visual cortex of postnatal day 1 versus day 21 rats revealed by suppression subtractive hybridization. Feng Y, et al. Gene, 2004 Mar 31. PMID 15033532
  5. ARTS and Siah collaborate in a pathway for XIAP degradation. Garrison JB, et al. Mol Cell, 2011 Jan 7. PMID 21185211, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
    Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC156532

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IEA
Inferred from Electronic Annotation
more info
  
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm annulus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
septin-4
Names
CE5B3 beta
apoptosis-related protein in the TGF-beta signaling pathway
arts
bradeion beta
brain protein H5
cell division control-related protein 2
expression gene 3 in rat visual cortex
expression gene 3-1 in rat visual cortex
peanut-like 2
peanut-like protein 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011893.2 → NP_001011893.2  septin-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    Q6XUZ6
    Related
    ENSRNOP00000072349.1, ENSRNOT00000088581.3
    Conserved Domains (1) summary
    pfam00735
    Location:43 → 315
    Septin

  2. NM_001408894.1 → NP_001395823.1  septin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    E9PST0
    Related
    ENSRNOP00000041380.4, ENSRNOT00000044226.6

  3. NM_001408895.1 → NP_001395824.1  septin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_001408896.1 → NP_001395825.1  septin-4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  5. NM_001414335.1 → NP_001401264.1  septin-4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    A0A096MJN4
    Related
    ENSRNOP00000068198.1, ENSRNOT00000076026.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    72863969..72888018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085565.2 → XP_038941493.1  septin-4 isoform X1

    Conserved Domains (1) summary
    pfam15548
    Location:14 → 538
    DUF4655; Domain of unknown function (DUF4655)

  2. XM_039085563.2 → XP_038941491.1  septin-4 isoform X8

    UniProtKB/TrEMBL
    A0A096MJT3
    Related
    ENSRNOP00000110392.1, ENSRNOT00000165333.1
    Conserved Domains (2) summary
    pfam00735
    Location:664 → 936
    Septin
    pfam15548
    Location:14 → 538
    DUF4655; Domain of unknown function (DUF4655)

  3. XM_063268699.1 → XP_063124769.1  septin-4 isoform X7

  4. XM_063268696.1 → XP_063124766.1  septin-4 isoform X4

  5. XM_039085566.2 → XP_038941494.1  septin-4 isoform X2

    Conserved Domains (1) summary
    pfam00735
    Location:182 → 454
    Septin

  6. XM_017597120.3 → XP_017452609.1  septin-4 isoform X3

    UniProtKB/TrEMBL
    A0A096MJW0
    Related
    ENSRNOP00000068282.2, ENSRNOT00000076050.4
    Conserved Domains (1) summary
    pfam00735
    Location:142 → 414
    Septin

  7. XM_063268697.1 → XP_063124767.1  septin-4 isoform X5

  8. XM_063268698.1 → XP_063124768.1  septin-4 isoform X6

RNA

  1. XR_005489745.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A096MJN4.1 GenPept UniProtKB/Swiss-Prot:A0A096MJN4

Gene LinkOut

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