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Mtmr4 myotubularin related protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287607, updated on 28-Oct-2024

Summary

Official Symbol
Mtmr4provided by RGD
Official Full Name
myotubularin related protein 4provided by RGD
Primary source
RGD:1310306
See related
EnsemblRapid:ENSRNOG00000007496 AllianceGenome:RGD:1310306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in response to denervation involved in regulation of muscle adaptation. Predicted to be located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Predicted to be active in early phagosome membrane and endosome membrane. Biomarker of muscular atrophy. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 186.2), Brain (RPKM 153.4) and 9 other tissues See more
Orthologs
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Genomic context

See Mtmr4 in Genome Data Viewer
Location:
10q26
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72890665..72913598)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72393411..72416342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74886600..74909532)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene uncharacterized LOC134480848 Neighboring gene septin 4 Neighboring gene heat shock transcription factor 5 Neighboring gene ring finger protein 43 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in early phagosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myotubularin-related protein 4
NP_001099297.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105827.4NP_001099297.4  myotubularin-related protein 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AT43, D3ZW40
    Related
    ENSRNOP00000086395.2, ENSRNOT00000099688.2
    Conserved Domains (3) summary
    cd13342
    Location:23136
    PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15733
    Location:11071166
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:127519
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    72890665..72913598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)