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Tom1l1 target of myb1 like 1 membrane trafficking protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 287622, updated on 28-Oct-2024

Summary

Official Symbol
Tom1l1provided by RGD
Official Full Name
target of myb1 like 1 membrane trafficking proteinprovided by RGD
Primary source
RGD:1562626
See related
EnsemblRapid:ENSRNOG00000002474 AllianceGenome:RGD:1562626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Srcasm; RGD1562626
Summary
Predicted to enable clathrin binding activity; protein kinase activator activity; and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Predicted to be located in cytosol. Predicted to be active in endosome and membrane. Orthologous to human TOM1L1 (target of myb1 like 1 membrane trafficking protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 137.2), Liver (RPKM 107.7) and 9 other tissues See more
Orthologs
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Genomic context

See Tom1l1 in Genome Data Viewer
Location:
10q26
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75961653..76005725, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (75464577..75508304, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (78173847..78219805, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480711 Neighboring gene syntaxin binding protein 4 Neighboring gene uncharacterized LOC134480712 Neighboring gene cytochrome c oxidase copper chaperone COX11 Neighboring gene target of myb1 like 3 membrane trafficking protein Neighboring gene transfer RNA alanine (anticodon AGC) 51 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TOM1-like protein 1
Names
Src-activating and signaling molecule protein
Target of Myb-like protein 1
target of myb1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253859.1NP_001240788.1  TOM1-like protein 1

    Status: VALIDATED

    Source sequence(s)
    BC169112, CK596986, CO568886
    UniProtKB/Swiss-Prot
    F1LM81
    UniProtKB/TrEMBL
    B5DFM1
    Related
    ENSRNOP00000003369.8, ENSRNOT00000003369.8
    Conserved Domains (2) summary
    cd03565
    Location:14154
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14237
    Location:198289
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    75961653..76005725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268709.1XP_063124779.1  TOM1-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHB0
  2. XM_039085577.2XP_038941505.1  TOM1-like protein 1 isoform X2

    UniProtKB/TrEMBL
    B5DFM1
    Conserved Domains (2) summary
    cd14237
    Location:121212
    GAT_TM1L1; canonical GAT domain found in target of Myb-like protein 1 (Tom1L1)
    cl02544
    Location:173
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
  3. XM_039085579.2XP_038941507.1  TOM1-like protein 1 isoform X3

    Conserved Domains (1) summary
    cl03906
    Location:142
    GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins
  4. XM_039085578.2XP_038941506.1  TOM1-like protein 1 isoform X3

    Conserved Domains (1) summary
    cl03906
    Location:142
    GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins

RNA

  1. XR_005489750.2 RNA Sequence