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Lrrc46 leucine rich repeat containing 46 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287653, updated on 28-Oct-2024

Summary

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Official Symbol
Lrrc46provided by RGD
Official Full Name
leucine rich repeat containing 46provided by RGD
Primary source
RGD:1303311
See related
EnsemblRapid:ENSRNOG00000009902 AllianceGenome:RGD:1303311
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Orthologous to human LRRC46 (leucine rich repeat containing 46). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 1785.8) See more
Orthologs
human mouse all
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Genomic context

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See Lrrc46 in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82517767..82530011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82021314..82033575, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84971674..84983867, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Sp6 transcription factor Neighboring gene secernin 2 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene oxysterol binding protein-like 7 Neighboring gene T-box transcription factor 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC94361

General protein information

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Preferred Names
leucine-rich repeat-containing protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004201.1 → NP_001004201.1  leucine-rich repeat-containing protein 46

    See identical proteins and their annotated locations for NP_001004201.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079258
    UniProtKB/Swiss-Prot
    Q6AXZ2
    Conserved Domains (3) summary
    sd00031
    Location:50 → 71
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:71 → 110
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:70 → 126
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82517767..82530011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247268.5 → XP_006247330.1  leucine-rich repeat-containing protein 46 isoform X1

    See identical proteins and their annotated locations for XP_006247330.1

    UniProtKB/TrEMBL
    A6HII6
    Conserved Domains (2) summary
    sd00031
    Location:50 → 71
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:60 → 177
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_039085605.2 → XP_038941533.1  leucine-rich repeat-containing protein 46 isoform X2

    UniProtKB/TrEMBL
    G3V7B2
    Related
    ENSRNOP00000013542.4, ENSRNOT00000013542.6
    Conserved Domains (2) summary
    sd00031
    Location:20 → 41
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:30 → 147
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXZ2.1 GenPept UniProtKB/Swiss-Prot:Q6AXZ2

Gene LinkOut

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