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Slc39a11 solute carrier family 39, member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287796, updated on 2-Nov-2024

Summary

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Official Symbol
Slc39a11provided by RGD
Official Full Name
solute carrier family 39, member 11provided by RGD
Primary source
RGD:1311981
See related
EnsemblRapid:ENSRNOG00000031213 AllianceGenome:RGD:1311981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion import across plasma membrane. Predicted to be located in Golgi apparatus; nucleus; and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 55.3), Kidney (RPKM 25.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc39a11 in Genome Data Viewer
Location:
10q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (98775155..99196302, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98275958..98697042, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (101754842..102169100, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549836 Neighboring gene uncharacterized LOC134480896 Neighboring gene microRNA 297 Neighboring gene uncharacterized LOC134480897 Neighboring gene uncharacterized LOC120095210 Neighboring gene transfer RNA alanine (anticodon UGC) 10 Neighboring gene somatostatin receptor 2 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene VCP nuclear cofactor family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. Martin AB, et al. J Nutr, 2013 Dec. PMID 24089422, Free PMC Article
  2. Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation. Kelleher SL, et al. J Cell Physiol, 2012 Apr. PMID 21702047, Free PMC Article
  3. Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter. Yu Y, et al. J Nutr Biochem, 2013 Oct. PMID 23643525
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables copper ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc transporter ZIP11
Names
ZIP-11
solute carrier family 39 (metal ion transporter), member 11
zrt- and Irt-like protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013042.2 → NP_001013060.1  zinc transporter ZIP11

    See identical proteins and their annotated locations for NP_001013060.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q6P6S2
    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    98775155..99196302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268767.1 → XP_063124837.1  zinc transporter ZIP11 isoform X7

  2. XM_039085657.2 → XP_038941585.1  zinc transporter ZIP11 isoform X6

    Conserved Domains (1) summary
    COG0428
    Location:1 → 292
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  3. XM_063268766.1 → XP_063124836.1  zinc transporter ZIP11 isoform X5

    UniProtKB/Swiss-Prot
    Q6P6S2

  4. XM_006247670.5 → XP_006247732.1  zinc transporter ZIP11 isoform X4

    See identical proteins and their annotated locations for XP_006247732.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  5. XM_017597148.3 → XP_017452637.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  6. XM_006247668.5 → XP_006247730.1  zinc transporter ZIP11 isoform X4

    See identical proteins and their annotated locations for XP_006247730.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  7. XM_039085656.2 → XP_038941584.1  zinc transporter ZIP11 isoform X4

    Related
    ENSRNOP00000098332.1, ENSRNOT00000120701.2
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  8. XM_039085655.2 → XP_038941583.1  zinc transporter ZIP11 isoform X2

    Conserved Domains (1) summary
    COG0428
    Location:23 → 359
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  9. XM_063268765.1 → XP_063124835.1  zinc transporter ZIP11 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZC3

  10. XM_006247664.5 → XP_006247726.1  zinc transporter ZIP11 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QK09
    Related
    ENSRNOP00000098333.2, ENSRNOT00000120702.2
    Conserved Domains (1) summary
    COG0428
    Location:38 → 374
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  11. XM_039085660.2 → XP_038941588.1  zinc transporter ZIP11 isoform X10

    Conserved Domains (1) summary
    COG0428
    Location:37 → 204
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  12. XM_039085659.2 → XP_038941587.2  zinc transporter ZIP11 isoform X9

  13. XM_039085658.2 → XP_038941586.1  zinc transporter ZIP11 isoform X8

    Conserved Domains (1) summary
    cl00437
    Location:6 → 114
    Zip; ZIP Zinc transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6S2.1 GenPept UniProtKB/Swiss-Prot:Q6P6S2

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