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Ube2v2 ubiquitin conjugating enzyme E2 V2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287927, updated on 2-Nov-2024

Summary

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Official Symbol
Ube2v2provided by RGD
Official Full Name
ubiquitin conjugating enzyme E2 V2provided by RGD
Primary source
RGD:727838
See related
EnsemblRapid:ENSRNOG00000001829 AllianceGenome:RGD:727838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MMS2
Summary
Involved in negative regulation of neuron apoptotic process; positive regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 189.4), Muscle (RPKM 155.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2v2 in Genome Data Viewer
Location:
11q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98808681..98842583)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (85304528..85338430)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (89557273..89591175)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene minichromosome maintenance complex component 4 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA polymerase II subunit M, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105268

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within error-free postreplication DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of UBC13-MMS2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin conjugating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 variant 2
Names
ubiquitin-conjugating enzyme E2v2
ubiquitin-conjugating enzyme variant MMS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183052.2 → NP_898875.1  ubiquitin-conjugating enzyme E2 variant 2

    See identical proteins and their annotated locations for NP_898875.1

    Status: VALIDATED

    Source sequence(s)
    FM082155, JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q7M767, Q8CHN0
    UniProtKB/TrEMBL
    A0A8I6AKD9, A6JSS2
    Conserved Domains (1) summary
    smart00212
    Location:14 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    98808681..98842583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597891.3 → XP_017453380.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN23, A0A8I6AJF4
    Conserved Domains (1) summary
    smart00212
    Location:29 → 160
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  2. XM_039088057.2 → XP_038943985.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKD9, A6JSS3
    Related
    ENSRNOP00000079261.2, ENSRNOT00000111871.2
    Conserved Domains (1) summary
    smart00212
    Location:18 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M767.3 GenPept UniProtKB/Swiss-Prot:Q7M767

Gene LinkOut

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