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Hic2 HIC ZBTB transcriptional repressor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287940, updated on 2-Nov-2024

Summary

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Official Symbol
Hic2provided by RGD
Official Full Name
HIC ZBTB transcriptional repressor 2provided by RGD
Primary source
RGD:1305338
See related
EnsemblRapid:ENSRNOG00000051458 AllianceGenome:RGD:1305338
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus and plasma membrane. Predicted to be active in nucleoplasm. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 16.2), Heart (RPKM 15.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hic2 in Genome Data Viewer
Location:
11q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97241308..97294429, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83737075..83789554, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87988213..88016825, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene serpin family D member 1 Neighboring gene transmembrane protein 191C Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene small nucleolar RNA SNORA51 Neighboring gene RIMS binding protein 3 Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene coiled-coil domain containing 116 Neighboring gene YdjC chitooligosaccharide deacetylase homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. Deltour S, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554746
  2. The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Deltour S, et al. Mol Cell Biol, 2002 Jul. PMID 12052894, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hypermethylated in cancer 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105862.2 → NP_001099332.1  hypermethylated in cancer 2 protein

    See identical proteins and their annotated locations for NP_001099332.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6GE12, A6JSM6, D4A9X7
    Related
    ENSRNOP00000072722.1, ENSRNOT00000079595.3
    Conserved Domains (5) summary
    sd00017
    Location:542 → 562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:25 → 144
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00096
    Location:540 → 562
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:582 → 607
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:510 → 559
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97241308..97294429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088073.2 → XP_038944001.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GE12, A6JSM6, D4A9X7
    Conserved Domains (5) summary
    sd00017
    Location:542 → 562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:25 → 144
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00096
    Location:540 → 562
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:582 → 607
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:510 → 559
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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