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Lsg1 large 60S subunit nuclear export GTPase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288029, updated on 17-Aug-2024

Summary

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Symbol
Lsg1provided by RGD
Full Name
large 60S subunit nuclear export GTPase 1provided by RGD
Primary source
RGD:1309089
See related
EnsemblRapid:ENSRNOG00000001727 AllianceGenome:RGD:1309089
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309089
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 99.6), Kidney (RPKM 84.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83648757..83673431)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (70132919..70168526)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73693862..73723457)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549085 Neighboring gene uncharacterized LOC134481097 Neighboring gene family with sequence similarity 43, member A Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene uncharacterized LOC102548792 Neighboring gene transmembrane protein 44 Neighboring gene uncharacterized LOC120095681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. Reynaud EG, et al. BMC Biol, 2005 Oct 7. PMID 16209721, Free PMC Article
  2. Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury. Price M, et al. Brain Res Mol Brain Res, 2003 Sep 10. PMID 14499481
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nuclear export IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Cajal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large subunit GTPase 1 homolog
NP_001013439.1
XP_038944038.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013421.1 → NP_001013439.1  large subunit GTPase 1 homolog

    See identical proteins and their annotated locations for NP_001013439.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091338
    UniProtKB/Swiss-Prot
    Q5BJT6
    UniProtKB/TrEMBL
    A0A8L2R9T6
    Related
    ENSRNOP00000002354.6, ENSRNOT00000002354.8
    Conserved Domains (2) summary
    cd01857
    Location:163 → 441
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:151 → 551
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    83648757..83673431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088110.2 → XP_038944038.1  large subunit GTPase 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6KTZ4
    Conserved Domains (2) summary
    PRK15494
    Location:334 → 453
    era; GTPase Era; Provisional
    cd01857
    Location:163 → 441
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJT6.1 GenPept UniProtKB/Swiss-Prot:Q5BJT6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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