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Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288088, updated on 2-Nov-2024

Summary

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Official Symbol
Ndufb4provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase subunit B4provided by RGD
Primary source
RGD:1307072
See related
EnsemblRapid:ENSRNOG00000002721 AllianceGenome:RGD:1307072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 3032.6), Muscle (RPKM 1787.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufb4 in Genome Data Viewer
Location:
11q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76569178..76575879)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63063723..63070426)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (65960277..65966899)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene follistatin-like 1 Neighboring gene uncharacterized LOC134481075 Neighboring gene ribosomal protein S11, pseudogene 13 Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene homogentisate 1, 2-dioxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. Murray J, et al. J Biol Chem, 2003 Sep 26. PMID 12857734
  2. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Murray J, et al. J Biol Chem, 2003 Apr 18. PMID 12611891
  4. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
  5. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NP_001032415.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037338.2 → NP_001032415.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D3ZV29, F1LPG5
    Related
    ENSRNOP00000003674.4, ENSRNOT00000003674.9
    Conserved Domains (1) summary
    pfam07225
    Location:5 → 128
    NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    76569178..76575879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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