U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cldnd1 claudin domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288182, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cldnd1provided by RGD
Official Full Name
claudin domain containing 1provided by RGD
Primary source
RGD:1359273
See related
EnsemblRapid:ENSRNOG00000001657 AllianceGenome:RGD:1359273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in apical plasma membrane. Orthologous to human CLDND1 (claudin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 146.6), Muscle (RPKM 128.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cldnd1 in Genome Data Viewer
Location:
11q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (55352321..55358779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (41883120..41889471, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43986352..43992703, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily K member 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene G protein-coupled receptor 15 Neighboring gene coproporphyrinogen oxidase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats. Matsuoka H, et al. Biochem Biophys Res Commun, 2018 Apr 15. PMID 29530526
  2. Predicted expansion of the claudin multigene family. Mineta K, et al. FEBS Lett, 2011 Feb 18. PMID 21276448
  3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When miR-124 is increased, CLDND1 mRNA translation is downregulated in the brain.
    Title: Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94479

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
claudin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006955.2 → NP_001006956.2  claudin domain-containing protein 1

    See identical proteins and their annotated locations for NP_001006956.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IQK9, G3V674, Q5XIN0
    Conserved Domains (1) summary
    cl21598
    Location:17 → 234
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    55352321..55358779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248204.5 → XP_006248266.3  claudin domain-containing protein 1 isoform X1

    Related
    ENSRNOP00000002260.4, ENSRNOT00000002260.6

  2. XM_006248206.5 → XP_006248268.1  claudin domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5XIN0
    Conserved Domains (1) summary
    cl21598
    Location:40 → 257
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. XM_063270411.1 → XP_063126481.1  claudin domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A6IQK9, G3V674
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools