Bace2 beta-secretase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bace2provided by RGD
Official Full Name: beta-secretase 2provided by RGD
Primary source: RGD:1303241
See related: EnsemblRapid:ENSRNOG00000001953 AllianceGenome:RGD:1303241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 61.5), Lung (RPKM 44.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (50176852..50258948)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (36707447..36789550)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (37798397..37880624)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

found by global gene expression profiling that BACE2 was up-regulated in the rat pancreatic beta-cell line INS1E stably transfected with human IAPP gene
Title: Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic β-cells.
Data show that astrocytes possess beta-secretase activity and produce amyloid-beta because of the activity of BACE2, but not BACE1, the expression of which is blocked at the translational level.
Title: β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.
The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.
Title: BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells.
Results describe the functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells.
Title: Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133630 (e-PCR)
- UniSTS:216913

RH134179 (e-PCR)
- UniSTS:217461

AU028944 (e-PCR)
- UniSTS:111841

Bace2 (e-PCR), detects polymorphism
- UniSTS:259043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in astrocyte activation	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-secretase 2

Names: beta-site APP-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase

NP_001002802.1

EC 3.4.23.45

XP_038944130.1

EC 3.4.23.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002802.2 → NP_001002802.1 beta-secretase 2 precursor

See identical proteins and their annotated locations for NP_001002802.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

B2GVB0, Q6IE75

UniProtKB/TrEMBL

A6IQF8

Related

ENSRNOP00000002679.4, ENSRNOT00000002679.9

Conserved Domains (2) summary

cd05473
Location:85 → 446

beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

pfam00026
Location:88 → 425

Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

50176852..50258948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088202.2 → XP_038944130.1 beta-secretase 2 isoform X1

Conserved Domains (1) summary

cd05473
Location:37 → 382

beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease