Psmg1 proteasome assembly chaperone 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmg1provided by RGD
Official Full Name: proteasome assembly chaperone 1provided by RGD
Primary source: RGD:1305454
See related: EnsemblRapid:ENSRNOG00000001643 AllianceGenome:RGD:1305454
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dscr2
Summary: Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and proteasome core complex assembly. Predicted to act upstream of or within cerebellar granule cell precursor proliferation. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in endoplasmic reticulum. Orthologous to human PSMG1 (proteasome assembly chaperone 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 98.1), Kidney (RPKM 80.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (48745581..48755040, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (35276080..35285541, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (36327798..36337289, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139029 (e-PCR)
- UniSTS:221115

AW552102 (e-PCR)
- UniSTS:180953

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome core complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteasome assembly chaperone 1

Names: Down syndrome critical region gene 2; Down syndrome critical region homolog 2; proteasome (prosome, macropain) assembly chaperone 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399237.1 → NP_001386166.1 proteasome assembly chaperone 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6KPT1

Related

ENSRNOP00000100896.1, ENSRNOT00000121972.1

Conserved Domains (1) summary

pfam16094
Location:2 → 288

PAC1; Proteasome assembly chaperone 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

48745581..48755040 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105891.1: Suppressed sequence

Description

NM_001105891.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.