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Donson DNA replication fork stabilization factor DONSON [ Rattus norvegicus (Norway rat) ]

Gene ID: 288257, updated on 2-Nov-2024

Summary

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Official Symbol
Donsonprovided by RGD
Official Full Name
DNA replication fork stabilization factor DONSONprovided by RGD
Primary source
RGD:1306823
See related
EnsemblRapid:ENSRNOG00000002012 AllianceGenome:RGD:1306823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in DNA-templated DNA replication and mitotic G2/M transition checkpoint. Predicted to be located in replication fork. Predicted to be part of replisome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 98.3), Spleen (RPKM 83.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Donson in Genome Data Viewer
Location:
11q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44405794..44419099, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30919834..30933150, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31834608..31847751, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene uncharacterized LOC134481057 Neighboring gene ATP synthase peripheral stalk subunit OSCP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Reynolds JJ, et al. Nat Genet, 2017 Apr. PMID 28191891, Free PMC Article
  2. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94546

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  
part_of replisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein downstream neighbor of Son
Names
downstream neighbor of SON

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008287.2 → NP_001008288.2  protein downstream neighbor of Son isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    E9PSU2

  2. NM_001399266.1 → NP_001386195.1  protein downstream neighbor of Son isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6ACX2, A6JLH3
    Related
    ENSRNOP00000089568.2, ENSRNOT00000093955.2
    Conserved Domains (1) summary
    PHA03378
    Location:6 → 102
    PHA03378; EBNA-3B; Provisional

  3. NM_001399267.1 → NP_001386196.1  protein downstream neighbor of Son isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6ACX2, A6JLH3
    Related
    ENSRNOP00000058017.3, ENSRNOT00000061304.5
    Conserved Domains (1) summary
    PHA03378
    Location:6 → 102
    PHA03378; EBNA-3B; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    44405794..44419099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270426.1 → XP_063126496.1  protein downstream neighbor of Son isoform X4

  2. XM_063270424.1 → XP_063126494.1  protein downstream neighbor of Son isoform X2

  3. XM_017597940.2 → XP_017453429.1  protein downstream neighbor of Son isoform X2

    UniProtKB/TrEMBL
    Q5U2V7

  4. XM_063270425.1 → XP_063126495.1  protein downstream neighbor of Son isoform X3

    UniProtKB/TrEMBL
    E9PSU2

  5. XM_017597939.3 → XP_017453428.1  protein downstream neighbor of Son isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACX2, A6JLH3, Q5U2V7
    Conserved Domains (1) summary
    PHA03378
    Location:6 → 102
    PHA03378; EBNA-3B; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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