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Ncam2 neural cell adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288280, updated on 2-Nov-2024

Summary

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Symbol
Ncam2provided by RGD
Full Name
neural cell adhesion molecule 2provided by RGD
Primary source
RGD:1303131
See related
EnsemblRapid:ENSRNOG00000002126 AllianceGenome:RGD:1303131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ocam; OCAM-GPI
Summary
Predicted to enable identical protein binding activity. Involved in axonal fasciculation. Predicted to be located in axon; nuclear body; and plasma membrane. Predicted to be active in synaptic membrane. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 225.2) and Testes (RPKM 23.3) See more
Orthologs
human mouse all
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Genomic context

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See Ncam2 in Genome Data Viewer
Location:
11q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (33591748..34078788)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (20104974..20592168)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (19669922..20705063)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480954 Neighboring gene poly(rC) binding protein 2, pseudogene 8 Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene transmembrane protein 258, pseudogene 5 Neighboring gene uncharacterized LOC134480956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential expression of the mammalian homologue of fasciclin II during olfactory development in vivo and in vitro. Hamlin JA, et al. J Comp Neurol, 2004 Jun 28. PMID 15174086
  2. Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. Kulahin N, et al. Structure, 2011 Feb 9. PMID 21300289
  3. Arx homeobox gene is essential for development of mouse olfactory system. Yoshihara S, et al. Development, 2005 Feb. PMID 15677725
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axonal fasciculation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule 2
Names
fasciclin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203409.2 → NP_981954.2  neural cell adhesion molecule 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    F1M8G9, Q6RKB3
    Related
    ENSRNOP00000002895.7, ENSRNOT00000002895.9
    Conserved Domains (8) summary
    smart00408
    Location:128 → 189
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cd00096
    Location:300 → 305
    Ig; Ig strand A [structural motif]
    cd05866
    Location:21 → 113
    IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
    cd20970
    Location:209 → 298
    IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
    cl11960
    Location:300 → 397
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    33591748..34078788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088218.2 → XP_038944146.1  neural cell adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7R3, A6JL49, Q6RKB2
    Related
    ENSRNOP00000074311.2, ENSRNOT00000082417.3
    Conserved Domains (8) summary
    smart00408
    Location:128 → 189
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cd00096
    Location:300 → 305
    Ig; Ig strand A [structural motif]
    cd05866
    Location:21 → 113
    IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
    cd20970
    Location:209 → 298
    IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
    cl11960
    Location:300 → 397
    Ig; Immunoglobulin domain

  2. XM_039088217.2 → XP_038944145.1  neural cell adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    Q6RKB3
    Conserved Domains (8) summary
    smart00408
    Location:128 → 189
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:496 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:592 → 676
    fn3; Fibronectin type III domain
    pfam13927
    Location:401 → 479
    Ig_3; Immunoglobulin domain
    cd00096
    Location:300 → 305
    Ig; Ig strand A [structural motif]
    cd05866
    Location:21 → 113
    IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
    cd20970
    Location:209 → 298
    IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
    cl11960
    Location:300 → 397
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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