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Rfc3 replication factor C subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288414, updated on 18-Sep-2024

Summary

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Official Symbol
Rfc3provided by RGD
Official Full Name
replication factor C subunit 3provided by RGD
Primary source
RGD:1306832
See related
EnsemblRapid:ENSRNOG00000001088 AllianceGenome:RGD:1306832
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to DNA binding activity; DNA clamp loader activity; and single-stranded DNA helicase activity. Predicted to be involved in several processes, including DNA repair; positive regulation of DNA-directed DNA polymerase activity; and response to organophosphorus. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 184.3), Spleen (RPKM 121.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rfc3 in Genome Data Viewer
Location:
12p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (5836546..5847331)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1000987..1011778)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1460581..1471344)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene StAR-related lipid transfer domain containing 13 Neighboring gene uncharacterized LOC102549089 Neighboring gene uncharacterized LOC134481142 Neighboring gene uncharacterized LOC102554571 Neighboring gene vomeronasal 2 receptor, pseudogene 97

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Replication clamps and clamp loaders. Hedglin M, et al. Cold Spring Harb Perspect Biol, 2013 Apr 1. PMID 23545418, Free PMC Article
  2. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Gwinn MR, et al. Environ Health Perspect, 2005 Aug. PMID 16079077, Free PMC Article
  3. Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. Ellison V, et al. J Biol Chem, 1998 Mar 6. PMID 9488738
  4. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
  5. Mechanisms and functions of DNA mismatch repair. Li GM. Cell Res, 2008 Jan. PMID 18157157

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC109141

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organophosphorus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 3
Names
replication factor C (activator 1) 3
replication factor C 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009629.1 → NP_001009629.1  replication factor C subunit 3

    See identical proteins and their annotated locations for NP_001009629.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088281
    UniProtKB/TrEMBL
    F7F7G0, Q5M830
    Related
    ENSRNOP00000001444.4, ENSRNOT00000001444.8
    Conserved Domains (3) summary
    cd00009
    Location:21 → 187
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK12402
    Location:3 → 339
    PRK12402; replication factor C small subunit 2; Reviewed
    pfam08542
    Location:250 → 337
    Rep_fac_C; Replication factor C C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    5836546..5847331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089148.2 → XP_038945076.1  replication factor C subunit 3 isoform X1

    Conserved Domains (1) summary
    PRK12402
    Location:82 → 293
    PRK12402; replication factor C small subunit 2; Reviewed
Nucleotide Protein Strain
Heading Accession and Version

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