Rasa4 RAS p21 protein activator 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasa4provided by RGD
Official Full Name: RAS p21 protein activator 4provided by RGD
Primary source: RGD:1565457
See related: EnsemblRapid:ENSRNOG00000001431 AllianceGenome:RGD:1565457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Capri; RGD1565457
Summary: Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Orthologous to several human genes including RASA4B (RAS p21 protein activator 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 105.7), Thymus (RPKM 42.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26189416..26216801, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20552805..20580177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23596989..23624386, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggested that the translocation of CAPRI to the plasma membranes regulates crucially cellular responses in mast cells.
Title: The plasma membrane shuttling of CAPRI is related to regulation of mast cell activation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127441 (e-PCR)
- UniSTS:210751

AA957504 (e-PCR)
- UniSTS:248142

AA957504 (e-PCR)
- UniSTS:261519

Rasa4 (e-PCR), detects polymorphism
- UniSTS:531381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras GTPase-activating protein 4; ras GTPase-activating protein 4B

Names: calcium-promoted RAS inactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432268.1 → NP_001419197.1 ras GTPase-activating protein 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J086, D3ZQH9
NM_001432269.1 → NP_001419198.1 ras GTPase-activating protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J088
NM_001432270.1 → NP_001419199.1 ras GTPase-activating protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J088
NM_001432271.1 → NP_001419200.1 ras GTPase-activating protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

26189416..26216801 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002727953.6 → XP_002727999.1 ras GTPase-activating protein 4B isoform X1

Related

ENSRNOP00000001943.6, ENSRNOT00000001943.10

Conserved Domains (7) summary

cd04054
Location:6 → 126

C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4

smart00323
Location:245 → 604

RasGAP; GTPase-activator protein for Ras-like GTPases

cd13372
Location:541 → 680

PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain

pfam00169
Location:566 → 671

PH; PH domain

pfam00779
Location:680 → 708

BTK; BTK motif

cl02569
Location:264 → 549

RasGAP; Ras GTPase Activating Domain

cl14603
Location:134 → 256

C2; C2 domain
XM_039090070.2 → XP_038945998.1 ras GTPase-activating protein 4B isoform X2

Conserved Domains (3) summary

cd13372
Location:191 → 330

PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain

pfam00779
Location:330 → 358

BTK; BTK motif

cl02569
Location:1 → 199

RasGAP; Ras GTPase Activating Domain