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Anapc5 anaphase-promoting complex subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288671, updated on 2-Nov-2024

Summary

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Official Symbol
Anapc5provided by RGD
Official Full Name
anaphase-promoting complex subunit 5provided by RGD
Primary source
RGD:1306125
See related
EnsemblRapid:ENSRNOG00000001316 AllianceGenome:RGD:1306125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
APC5
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 852.9), Muscle (RPKM 794.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anapc5 in Genome Data Viewer
Location:
12q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39409519..39442518)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33748709..33781709)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39209134..39242696)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 34 Neighboring gene uncharacterized LOC120095970 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2 Neighboring gene U4 spliceosomal RNA Neighboring gene large ribosomal subunit protein uL30-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Song MS, et al. Cell, 2011 Jan 21. PMID 21241890, Free PMC Article
  2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
  4. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 5
Names
cyclosome subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080147.2 → NP_001073616.1  anaphase-promoting complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_001073616.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    A1L1K3
    UniProtKB/TrEMBL
    A0A0H2UH97
    Related
    ENSRNOP00000086139.1, ENSRNOT00000094951.2
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  2. NM_001401087.1 → NP_001388016.1  anaphase-promoting complex subunit 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J175
    Related
    ENSRNOP00000001794.9, ENSRNOT00000001794.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    39409519..39442518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L1K3.1 GenPept UniProtKB/Swiss-Prot:A1L1K3

Gene LinkOut

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