Srsf9 serine and arginine rich splicing factor 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srsf9provided by RGD
Official Full Name: serine and arginine rich splicing factor 9provided by RGD
Primary source: RGD:1309495
See related: EnsemblRapid:ENSRNOG00000001163 AllianceGenome:RGD:1309495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sfrs9
Summary: Predicted to enable RNA binding activity and protein domain specific binding activity. Involved in response to alkaloid and response to toxic substance. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear speck. Orthologous to human SRSF9 (serine and arginine rich splicing factor 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 105.2), Kidney (RPKM 92.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46938948..46945213, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41278225..41284502, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47039714..47046022, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141055 (e-PCR)
- UniSTS:223055

AU046359 (e-PCR)
- UniSTS:111517

AU028925 (e-PCR)
- UniSTS:111860

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 9

Names: splicing factor, arginine/serine-rich 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009255.1 → NP_001009255.1 serine/arginine-rich splicing factor 9

See identical proteins and their annotated locations for NP_001009255.1

Status: VALIDATED

Source sequence(s)

BC087684

UniProtKB/Swiss-Prot

Q5PPI1

UniProtKB/TrEMBL

A0A8I6B311, A6J1V2

Related

ENSRNOP00000095591.1, ENSRNOT00000106311.2

Conserved Domains (2) summary

cd12598
Location:15 → 86

RRM1_SRSF9; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)

cd12768
Location:103 → 186

RRM2_SRSF9; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)