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Chit1 chitinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289032, updated on 10-Jul-2024

Summary

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Official Symbol
Chit1provided by RGD
Official Full Name
chitinase 1provided by RGD
Primary source
RGD:1305646
See related
EnsemblRapid:ENSRNOG00000028072 AllianceGenome:RGD:1305646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chitin binding activity and endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 45.0), Spleen (RPKM 21.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chit1 in Genome Data Viewer
Location:
13q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48117886..48165645)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45565841..45613593)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50947020..50994644)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096251 Neighboring gene fibromodulin Neighboring gene BTG anti-proliferation factor 2 Neighboring gene uncharacterized LOC102552406 Neighboring gene chitinase 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of rat chitotriosidase. Chen XH, et al. DNA Seq, 2008 Apr. PMID 17852345
  2. Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. Verwer PE, et al. PLoS One, 2013. PMID 24155872, Free PMC Article
  3. Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates. Bussink AP, et al. FEBS J, 2009 Oct. PMID 19725875
  4. The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis. Raafat Ibrahim R, et al. Redox Rep, 2022 Dec. PMID 35094663, Free PMC Article
  5. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. Boot RG, et al. J Biol Chem, 2001 Mar 2. PMID 11085997

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis.
    Title: The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis.
  2. Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity.
    Title: Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats.
  3. Expression of cloned cDNA of chitotriosidase demonstrates that the encoded protein is secreted extracellularly and has chitinolytic activity.
    Title: Molecular cloning and characterization of rat chitotriosidase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables endochitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chitotriosidase-1
Names
chitinase 1 (chitotriosidase)
NP_001073157.1
NP_001257775.1
NP_001257776.1
NP_001257777.1
XP_038946364.1
XP_038946365.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079689.2 → NP_001073157.1  chitotriosidase-1 precursor

    See identical proteins and their annotated locations for NP_001073157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (bChiV_5) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0S5V8, A6ICA4
    Related
    ENSRNOP00000070204.1, ENSRNOT00000080768.3
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:416 → 463
    ChtBD2; Chitin-binding domain type 2

  2. NM_001270846.1 → NP_001257775.1  chitotriosidase-1 precursor

    See identical proteins and their annotated locations for NP_001257775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (bChiV_4) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0S5V8, A6ICA4
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:416 → 463
    ChtBD2; Chitin-binding domain type 2

  3. NM_001270847.1 → NP_001257776.1  chitotriosidase-1 precursor

    See identical proteins and their annotated locations for NP_001257776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (bChiV_3) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0S5V8, A6ICA4
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:416 → 463
    ChtBD2; Chitin-binding domain type 2

  4. NM_001270848.1 → NP_001257777.1  chitotriosidase-1 precursor

    See identical proteins and their annotated locations for NP_001257777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (bChiV_2) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0S5V8, A6ICA4
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:416 → 463
    ChtBD2; Chitin-binding domain type 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    48117886..48165645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090437.2 → XP_038946365.1  chitotriosidase-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV32
    Related
    ENSRNOP00000096437.1, ENSRNOT00000099352.2
    Conserved Domains (1) summary
    cd02872
    Location:24 → 345
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

  2. XM_039090436.2 → XP_038946364.1  chitotriosidase-1 isoform X1

    UniProtKB/TrEMBL
    F7ER89
    Related
    ENSRNOP00000036477.6, ENSRNOT00000035658.7
    Conserved Domains (2) summary
    cd02872
    Location:14 → 373
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:406 → 453
    ChtBD2; Chitin-binding domain type 2
Nucleotide Protein Strain
Heading Accession and Version

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