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Tmem9 transmembrane protein 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289046, updated on 10-Oct-2024

Summary

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Official Symbol
Tmem9provided by RGD
Official Full Name
transmembrane protein 9provided by RGD
Primary source
RGD:1307922
See related
EnsemblRapid:ENSRNOG00000010204 AllianceGenome:RGD:1307922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 123.8), Brain (RPKM 118.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem9 in Genome Data Viewer
Location:
13q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50008829..50027556)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47458486..47475832)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52854031..52871300)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene uncharacterized LOC134481564

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. Kveine M, et al. Biochem Biophys Res Commun, 2002 Oct 4. PMID 12359240
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proton-transporting V-type ATPase complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proton-transporting V-type ATPase complex assembly regulator TMEM9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105953.2 → NP_001099423.2  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

    See identical proteins and their annotated locations for NP_001099423.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC169086, JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JUD1, A0A8J8YFY6, A6ICH5, B5DFJ7, F7F2S9
    Conserved Domains (1) summary
    pfam05434
    Location:44 → 182
    Tmemb_9; TMEM9

  2. NM_001277263.1 → NP_001264192.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

    See identical proteins and their annotated locations for NP_001264192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC169086, JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JUD1, A0A8J8YFY6, A6ICH5, B5DFJ7, F7F2S9
    Related
    ENSRNOP00000013738.8, ENSRNOT00000013738.8
    Conserved Domains (1) summary
    pfam05434
    Location:44 → 182
    Tmemb_9; TMEM9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50008829..50027556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272090.1 → XP_063128160.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUD1, A6ICH5, B5DFJ7, F7F2S9
Nucleotide Protein Strain
Heading Accession and Version

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