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Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289080, updated on 17-Aug-2024

Summary

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Official Symbol
Ralgdsl1provided by RGD
Official Full Name
ral guanine nucleotide dissociation stimulator like 1provided by RGD
Primary source
RGD:1308947
See related
EnsemblRapid:ENSRNOG00000002347 AllianceGenome:RGD:1308947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rgl1
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Orthologous to human RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 162.6), Heart (RPKM 100.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67184402..67454019, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (64634489..64904170, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (69909122..70174590, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene uncharacterized LOC102551528 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene uncharacterized LOC134481515 Neighboring gene actin related protein 2/3 complex, subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105957.2 → NP_001099427.2  ral guanine nucleotide dissociation stimulator-like 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICT7, D3ZS31
    Related
    ENSRNOP00000063014.2, ENSRNOT00000067135.3
    Conserved Domains (3) summary
    smart00229
    Location:100 → 231
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:263 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:682 → 768
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    67184402..67454019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272095.1 → XP_063128165.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGN1, A6ICT7

  2. XM_017598701.3 → XP_017454190.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    UniProtKB/TrEMBL
    A6ICT7, D3ZS31
    Conserved Domains (3) summary
    smart00229
    Location:100 → 231
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:263 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd17210
    Location:682 → 768
    RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

  3. XM_008769610.4 → XP_008767832.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGN1, A6ICT7
    Related
    ENSRNOP00000092177.1, ENSRNOT00000098745.2
    Conserved Domains (3) summary
    cd00153
    Location:646 → 731
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:63 → 194
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:226 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_006249982.5 → XP_006250044.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006250044.1

    UniProtKB/TrEMBL
    A6ICT6, A6ICT7
    Related
    ENSRNOP00000069394.3, ENSRNOT00000083995.3
    Conserved Domains (3) summary
    cd00153
    Location:648 → 733
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:65 → 196
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:228 → 497
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_039090443.2 → XP_038946371.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

    Conserved Domains (3) summary
    smart00229
    Location:100 → 231
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:263 → 532
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl28922
    Location:682 → 703
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. XM_063272096.1 → XP_063128166.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JV91
Nucleotide Protein Strain
Heading Accession and Version

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