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Dpt dermatopontin [ Rattus norvegicus (Norway rat) ]

Gene ID: 289178, updated on 28-Oct-2024

Summary

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Official Symbol
Dptprovided by RGD
Official Full Name
dermatopontinprovided by RGD
Primary source
RGD:1307176
See related
EnsemblRapid:ENSRNOG00000002947 AllianceGenome:RGD:1307176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human DPT (dermatopontin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 892.0), Heart (RPKM 735.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dpt in Genome Data Viewer
Location:
13q23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79656341..79684759)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77123224..77151646)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83073307..83102404)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096206 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546371 Neighboring gene uncharacterized LOC134481525 Neighboring gene uncharacterized LOC108352565 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro. Liu X, et al. Matrix Biol, 2013 Jan. PMID 23262218
  2. Increased expression of dermatopontin mRNA in the infarct zone of experimentally induced myocardial infarction in rats: comparison with decorin and type I collagen mRNAs. Takemoto S, et al. Basic Res Cardiol, 2002 Nov. PMID 12395208
  3. The role of dermatopontin in the stromal organization of the cornea. Cooper LJ, et al. Invest Ophthalmol Vis Sci, 2006 Aug. PMID 16877395, Free PMC Article
  4. Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence. Tzen CY, et al. Exp Cell Res, 2004 Mar 10. PMID 14980498
  5. Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis. Takeda U, et al. J Invest Dermatol, 2002 Sep. PMID 12230512

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DPT participates in the ventricular remodeling process after MI and may act as a potential therapeutic target for ventricular remodeling.
    Title: Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro.
  2. Coexpression of dermatopontin mRNA with decorin and type I collagen mRNAs suggests that dermatopontin plays role in ECM (fibrillar collagen matrix) reformation in myocardial infarct along with decorin and type I collagen. (dermatopontin)
    Title: Increased expression of dermatopontin mRNA in the infarct zone of experimentally induced myocardial infarction in rats: comparison with decorin and type I collagen mRNAs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dermatopontin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401366.1 → NP_001388295.1  dermatopontin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A096MJF1, B2RZ77
    Related
    ENSRNOP00000068106.1, ENSRNOT00000077070.4

  2. NM_001401367.1 → NP_001388296.1  dermatopontin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IDF3
    Related
    ENSRNOP00000069812.3, ENSRNOT00000079796.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    79656341..79684759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105965.2: Suppressed sequence

    Description
    NM_001105965.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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