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Gpr161 G protein-coupled receptor 161 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289180, updated on 14-Nov-2024

Summary

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Official Symbol
Gpr161provided by RGD
Official Full Name
G protein-coupled receptor 161provided by RGD
Primary source
RGD:1563245
See related
EnsemblRapid:ENSRNOG00000003073 AllianceGenome:RGD:1563245
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563245
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium; glial cell projection; and neuron projection. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in medulloblastoma. Orthologous to human GPR161 (G protein-coupled receptor 161). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 37.8), Lung (RPKM 31.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr161 in Genome Data Viewer
Location:
13q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80111271..80156517)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77578257..77623661)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83530389..83576117)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 2 Neighboring gene TOR signaling pathway regulator Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene adenylate cyclase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Mukhopadhyay S, et al. Cell, 2013 Jan 17. PMID 23332756
  2. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. Badgandi HB, et al. J Cell Biol, 2017 Mar 6. PMID 28154160, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G protein-coupled receptor 161; G-protein coupled receptor 161

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80111271..80156517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272753.1 → XP_063128823.1  G-protein coupled receptor 161

    UniProtKB/TrEMBL
    F1M5Q2

  2. XM_063272754.1 → XP_063128824.1  G-protein coupled receptor 161

    UniProtKB/TrEMBL
    F1M5Q2
    Related
    ENSRNOP00000004104.6, ENSRNOT00000004104.8

  3. XM_017598995.3 → XP_017454484.1  G-protein coupled receptor 161

    UniProtKB/TrEMBL
    F1M5Q2
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191672.1: Suppressed sequence

    Description
    NM_001191672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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