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Tmco1 transmembrane and coiled-coil domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289196, updated on 14-Nov-2024

Summary

Official Symbol
Tmco1provided by RGD
Official Full Name
transmembrane and coiled-coil domains 1provided by RGD
Primary source
RGD:1359178
See related
EnsemblRapid:ENSRNOG00000003928 AllianceGenome:RGD:1359178
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel activity and ribosome binding activity. Predicted to be involved in several processes, including ER overload response; endoplasmic reticulum calcium ion homeostasis; and multi-pass transmembrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 168.0), Kidney (RPKM 153.1) and 9 other tissues See more
Orthologs
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Genomic context

See Tmco1 in Genome Data Viewer
Location:
13q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (81993172..82016496)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79460229..79483557)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85465015..85559113)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uridine-cytidine kinase 2 Neighboring gene aldehyde dehydrogenase 9 family, member A1 Neighboring gene NOP10 ribonucleoprotein like 2 Neighboring gene microsomal glutathione S-transferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC109554

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in ER overload response IEA
Inferred from Electronic Annotation
more info
 
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in ER overload response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in multi-pass transmembrane protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in multi-pass transmembrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in multi-pass transmembrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of multi-pass translocon complex IEA
Inferred from Electronic Annotation
more info
 
part_of multi-pass translocon complex ISO
Inferred from Sequence Orthology
more info
 
part_of multi-pass translocon complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
calcium load-activated calcium channel
Names
CLAC channel
GEL complex subunit TMCO1
meg-2-like protein
putative membrane protein
transmembrane and coiled-coil domain-containing protein 1
transmembrane and coiled-coil domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009631.1NP_001009631.1  calcium load-activated calcium channel

    See identical proteins and their annotated locations for NP_001009631.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088319
    UniProtKB/Swiss-Prot
    Q5I0H4, Q71DI0
    UniProtKB/TrEMBL
    A0A8L2Q2R5, A6IDL2
    Related
    ENSRNOP00000074404.3, ENSRNOT00000082991.3
    Conserved Domains (1) summary
    pfam01956
    Location:8165
    DUF106; Integral membrane protein DUF106

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    81993172..82016496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)