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Cox20 cytochrome c oxidase assembly factor COX20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289278, updated on 10-Jul-2024

Summary

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Official Symbol
Cox20provided by RGD
Official Full Name
cytochrome c oxidase assembly factor COX20provided by RGD
Primary source
RGD:1309105
See related
EnsemblRapid:ENSRNOG00000076247 AllianceGenome:RGD:1309105
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam36a; RGD1309105
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX20 (cytochrome c oxidase assembly factor COX20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 500.8), Thymus (RPKM 406.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox20 in Genome Data Viewer
Location:
13q25
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (92592260..92604129)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (90065900..90075386)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (96219853..96224023)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene chromosome 13 C1orf202 homolog Neighboring gene basic transcription factor 3, pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein U Neighboring gene 60S ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia. Szklarczyk R, et al. Hum Mol Genet, 2013 Feb 15. PMID 23125284
  2. Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase. Bourens M, et al. Hum Mol Genet, 2014 Jun 1. PMID 24403053, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome c oxidase assembly factor COX20
Names
COX20 Cox2 chaperone homolog
COX20 cytochrome C oxidase assembly factor
family with sequence similarity 36, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105976.1 → NP_001099446.1  cytochrome c oxidase assembly factor COX20

    See identical proteins and their annotated locations for NP_001099446.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A0A8I5ZSY5, A6JGE3
    Related
    ENSRNOP00000100989.1, ENSRNOT00000159881.1
    Conserved Domains (1) summary
    pfam12597
    Location:13 → 97
    DUF3767; Protein of unknown function (DUF3767)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    92592260..92604129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090533.2 → XP_038946461.1  cytochrome c oxidase assembly factor COX20 isoform X1

    Conserved Domains (1) summary
    pfam12597
    Location:13 → 76
    DUF3767; Protein of unknown function (DUF3767)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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