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Tfb2m transcription factor B2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 289307, updated on 2-Nov-2024

Summary

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Symbol
Tfb2mprovided by RGD
Full Name
transcription factor B2, mitochondrialprovided by RGD
Primary source
RGD:1307091
See related
EnsemblRapid:ENSRNOG00000002695 AllianceGenome:RGD:1307091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 193.3), Muscle (RPKM 177.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tfb2m in Genome Data Viewer
Location:
13q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93810859..93828678, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91278889..91296709, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97820493..97838275, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene uncharacterized LOC108352579 Neighboring gene ribosomal protein L23,pseudogene 6 Neighboring gene uncharacterized LOC108352581 Neighboring gene consortin, connexin sorting protein Neighboring gene saccharopine dehydrogenase (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Watanabe A, et al. Cardiovasc Res, 2011 Apr 1. PMID 21113058
  2. Structural Basis of Mitochondrial Transcription Initiation. Hillen HS, et al. Cell, 2017 Nov 16. PMID 29149603, Free PMC Article
  3. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. Litonin D, et al. J Biol Chem, 2010 Jun 11. PMID 20410300, Free PMC Article
  4. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg M, et al. Nat Genet, 2002 Jul. PMID 12068295
  5. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription in cardiac myocytes.
    Title: Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitochondrial transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables mitochondrial transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at mitochondrial promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at mitochondrial promoter ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at mitochondrial promoter ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dimethyladenosine transferase 2, mitochondrial
Names
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
dimethyladenosine transferase 2, mitochondrial-like
mitochondrial 12S rRNA dimethylase 2
mitochondrial transcription factor B2
mtTFB2
NP_001008294.1
XP_008768039.1
XP_038946480.1
XP_038946481.1
XP_063128234.1
XP_063128235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008293.1 → NP_001008294.1  dimethyladenosine transferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001008294.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085870
    UniProtKB/Swiss-Prot
    Q5U2T7
    UniProtKB/TrEMBL
    A6JGF4
    Related
    ENSRNOP00000003618.3, ENSRNOT00000003618.5
    Conserved Domains (1) summary
    cl17173
    Location:82 → 378
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    93810859..93828678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090552.2 → XP_038946480.1  dimethyladenosine transferase 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:84 → 270
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_008769817.4 → XP_008768039.1  dimethyladenosine transferase 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZY51
    Related
    ENSRNOP00000084899.1, ENSRNOT00000086734.3
    Conserved Domains (1) summary
    cl17173
    Location:84 → 266
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_063272164.1 → XP_063128234.1  dimethyladenosine transferase 2, mitochondrial isoform X2

  4. XM_039090553.2 → XP_038946481.1  dimethyladenosine transferase 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:84 → 266
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_063272165.1 → XP_063128235.1  dimethyladenosine transferase 2, mitochondrial isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2T7.1 GenPept UniProtKB/Swiss-Prot:Q5U2T7

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