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Acbd3 acyl-CoA binding domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289312, updated on 2-Nov-2024

Summary

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Official Symbol
Acbd3provided by RGD
Official Full Name
acyl-CoA binding domain containing 3provided by RGD
Primary source
RGD:727851
See related
EnsemblRapid:ENSRNOG00000003185 AllianceGenome:RGD:727851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DAP; GOCAP1; GOLPH1
Summary
Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in steroid biosynthetic process. Located in Golgi membrane. Orthologous to human ACBD3 (acyl-CoA binding domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 88.2), Kidney (RPKM 79.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acbd3 in Genome Data Viewer
Location:
13q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94987643..95016356)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92455813..92484556)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99004942..99035520)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene transfer RNA proline (anticodon UGG) Neighboring gene Mix paired-like homeobox 1 Neighboring gene uncharacterized LOC134481537 Neighboring gene uncharacterized LOC102553824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. Klima M, et al. Sci Rep, 2016 Mar 24. PMID 27009356, Free PMC Article
  2. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Blanco EH, et al. Neuropeptides, 2011 Aug. PMID 21624661
  3. Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. Ruppelt A, et al. J Immunol, 2007 Oct 15. PMID 17911601
  4. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi resident protein GCP60
Names
DMT1-associated protein
acyl-CoA-binding domain-containing protein 3
acyl-Coenzyme A binding domain containing 3
golgi complex-associated protein 1
golgi phosphoprotein 1
neurotrophin receptor alike death domain protein
p75-like apoptosis-inducing death domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182843.2 → NP_878263.2  Golgi resident protein GCP60

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JGH4
    Related
    ENSRNOT00000004293.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    94987643..95016356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNY6.3 GenPept UniProtKB/Swiss-Prot:Q7TNY6

Gene LinkOut

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