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Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289400, updated on 2-Nov-2024

Summary

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Official Symbol
Camsap2provided by RGD
Official Full Name
calmodulin regulated spectrin-associated protein family, member 2provided by RGD
Primary source
RGD:1310950
See related
EnsemblRapid:ENSRNOG00000008741 AllianceGenome:RGD:1310950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Camsap1l1; RGD1310950
Summary
Predicted to enable microtubule minus-end binding activity. Involved in axon development and regulation of dendrite development. Predicted to be located in Golgi apparatus; cytosol; and microtubule cytoskeleton. Predicted to colocalize with microtubule minus-end. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 292.1), Lung (RPKM 162.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Camsap2 in Genome Data Viewer
Location:
13q13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50274950..50354298, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47723251..47802606, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53145712..53225349, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096220 Neighboring gene innate immunity activator Neighboring gene G protein-coupled receptor 25 Neighboring gene uncharacterized LOC134481565 Neighboring gene ribosomal protein L31 like 9 Neighboring gene uncharacterized LOC102547307 Neighboring gene DEAD-box helicase 59

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization. Mao BP, et al. Endocrinology, 2019 Jun 1. PMID 30994903, Free PMC Article
  2. Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development. Yau KW, et al. Neuron, 2014 Jun 4. PMID 24908486
  3. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Wu J, et al. Dev Cell, 2016 Oct 10. PMID 27666745
  4. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. Tanaka N, et al. Proc Natl Acad Sci U S A, 2012 Dec 4. PMID 23169647, Free PMC Article
  5. Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Jiang K, et al. Dev Cell, 2014 Feb 10. PMID 24486153

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, CAMSAP2 is a regulator of microtubule and actin dynamics in Sertoli cells to support blood-testis barrier dynamics and spermatogenesis.
    Title: CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of organelle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule end ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule minus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule minus-end ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule minus-end ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calmodulin-regulated spectrin-associated protein 2
Names
calmodulin regulated spectrin-associated protein 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134503.2 → NP_001127975.1  calmodulin-regulated spectrin-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001127975.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    A0A0G2K7K9, D4AEC2
    UniProtKB/TrEMBL
    A0A8I6A5G7
    Conserved Domains (4) summary
    pfam08683
    Location:1331 → 1449
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:237 → 315
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:737 → 787
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    cl26464
    Location:915 → 1028
    Atrophin-1; Atrophin-1 family

  2. NM_001415803.1 → NP_001402732.1  calmodulin-regulated spectrin-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000088623.1, ENSRNOT00000098757.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50274950..50354298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272200.1 → XP_063128270.1  calmodulin-regulated spectrin-associated protein 2 isoform X5

    Related
    ENSRNOP00000106071.1, ENSRNOT00000168494.1

  2. XM_039090610.2 → XP_038946538.1  calmodulin-regulated spectrin-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A5H1ZRV8, A0A8I6A5G7
    Related
    ENSRNOP00000074249.2, ENSRNOT00000091015.3
    Conserved Domains (4) summary
    PHA03247
    Location:904 → 1017
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:226 → 304
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:1329 → 1447
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:726 → 776
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  3. XM_063272199.1 → XP_063128269.1  calmodulin-regulated spectrin-associated protein 2 isoform X4

  4. XM_039090612.2 → XP_038946540.1  calmodulin-regulated spectrin-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A5G7
    Conserved Domains (4) summary
    PHA03247
    Location:915 → 1028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237 → 315
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:737 → 787
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    cl07883
    Location:1340 → 1400
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

  5. XM_039090609.2 → XP_038946537.1  calmodulin-regulated spectrin-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5G7
    Related
    ENSRNOP00000057155.3, ENSRNOT00000060410.6
    Conserved Domains (4) summary
    PHA03247
    Location:915 → 1028
    PHA03247; large tegument protein UL36; Provisional
    pfam11971
    Location:237 → 315
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:1340 → 1458
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam17095
    Location:737 → 787
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AEC2.1 GenPept UniProtKB/Swiss-Prot:D4AEC2

Gene LinkOut

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