U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289456, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hsd17b11provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 11provided by RGD
Primary source
RGD:1303235
See related
EnsemblRapid:ENSRNOG00000002210 AllianceGenome:RGD:1303235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dhrs8
Summary
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 1314.4), Kidney (RPKM 343.7) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hsd17b11 in Genome Data Viewer
Location:
14p22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5997893..6047816)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5693304..5743157)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7054724..7104567)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SPARC like 1 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene nudix hydrolase 9 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis. Thomes PG, et al. J Biol Chem, 2023 Apr. PMID 36849008, Free PMC Article
  2. Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily. Keller B, et al. Mol Cell Endocrinol, 2009 Mar 25. PMID 18775470
  3. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Chai Z, et al. Endocrinology, 2003 May. PMID 12697717
  4. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto Y, et al. Biochim Biophys Acta, 2004 Feb 2. PMID 14741744
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hydroxysteroid 17beta-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis.
    Title: Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis.
  2. The localization studies on rat short-chain dehydrogenases/reductases dhrs7b and dhrs8, are shown.
    Title: Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC93725

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
estradiol 17-beta-dehydrogenase 11
Names
17-beta-HSD 11
17-beta-HSD XI
17-beta-hydroxysteroid dehydrogenase 11
17-beta-hydroxysteroid dehydrogenase XI
17bHSD11
17betaHSD11
17betaHSDXI
dehydrogenase/reductase SDR family member 8
NP_001004209.1
XP_006250689.1
XP_006250691.1
XP_063128963.1
XP_063128964.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004209.1 → NP_001004209.1  estradiol 17-beta-dehydrogenase 11 precursor

    See identical proteins and their annotated locations for NP_001004209.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078929
    UniProtKB/Swiss-Prot
    Q6AYS8
    Conserved Domains (2) summary
    cd05339
    Location:38 → 277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    5997893..6047816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250629.5 → XP_006250691.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    See identical proteins and their annotated locations for XP_006250691.1

    UniProtKB/Swiss-Prot
    Q6AYS8
    Related
    ENSRNOP00000003004.3, ENSRNOT00000003004.8
    Conserved Domains (2) summary
    cd05339
    Location:38 → 277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase

  2. XM_063272893.1 → XP_063128963.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYS8

  3. XM_063272894.1 → XP_063128964.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYS8

  4. XM_006250627.5 → XP_006250689.1  estradiol 17-beta-dehydrogenase 11 isoform X1

    See identical proteins and their annotated locations for XP_006250689.1

    UniProtKB/Swiss-Prot
    Q6AYS8
    Conserved Domains (2) summary
    cd05339
    Location:38 → 277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYS8.1 GenPept UniProtKB/Swiss-Prot:Q6AYS8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous