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Klhl8 kelch-like family member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289457, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl8provided by RGD
Official Full Name
kelch-like family member 8provided by RGD
Primary source
RGD:1304685
See related
EnsemblRapid:ENSRNOG00000002214 AllianceGenome:RGD:1304685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL8 (kelch like family member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 134.7), Muscle (RPKM 103.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl8 in Genome Data Viewer
Location:
14p22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6112472..6158001)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5807795..5853325)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7169517..7215025)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 9 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene ALF transcription elongation factor 1 Neighboring gene similar to human chromosome 4 open reading frame 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Control of rapsyn stability by the CUL-3-containing E3 ligase complex. Nam S, et al. J Biol Chem, 2009 Mar 20. PMID 19158078, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 8
Names
kelch-like 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105995.1 → NP_001099465.1  kelch-like protein 8

    See identical proteins and their annotated locations for NP_001099465.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474022
    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5
    Conserved Domains (5) summary
    smart00612
    Location:509 → 555
    Kelch; Kelch domain
    PHA03098
    Location:61 → 536
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 400
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:58 → 162
    BTB; BTB/POZ domain
    pfam07707
    Location:170 → 272
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    6112472..6158001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770006.4 → XP_008768228.1  kelch-like protein 8 isoform X1

    See identical proteins and their annotated locations for XP_008768228.1

    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5
    Related
    ENSRNOP00000070593.2, ENSRNOT00000081600.3
    Conserved Domains (5) summary
    smart00612
    Location:509 → 555
    Kelch; Kelch domain
    PHA03098
    Location:61 → 536
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 400
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:58 → 162
    BTB; BTB/POZ domain
    pfam07707
    Location:170 → 272
    BACK; BTB And C-terminal Kelch

  2. XM_008770005.4 → XP_008768227.1  kelch-like protein 8 isoform X1

    See identical proteins and their annotated locations for XP_008768227.1

    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5
    Conserved Domains (5) summary
    smart00612
    Location:509 → 555
    Kelch; Kelch domain
    PHA03098
    Location:61 → 536
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 400
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:58 → 162
    BTB; BTB/POZ domain
    pfam07707
    Location:170 → 272
    BACK; BTB And C-terminal Kelch

  3. XM_008770004.4 → XP_008768226.1  kelch-like protein 8 isoform X1

    See identical proteins and their annotated locations for XP_008768226.1

    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5
    Related
    ENSRNOP00000111584.1, ENSRNOT00000159280.1
    Conserved Domains (5) summary
    smart00612
    Location:509 → 555
    Kelch; Kelch domain
    PHA03098
    Location:61 → 536
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 400
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:58 → 162
    BTB; BTB/POZ domain
    pfam07707
    Location:170 → 272
    BACK; BTB And C-terminal Kelch

  4. XM_063272896.1 → XP_063128966.1  kelch-like protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5

  5. XM_063272895.1 → XP_063128965.1  kelch-like protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYB7, A6K5U5
Nucleotide Protein Strain
Heading Accession and Version

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