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Mrpl1 mitochondrial ribosomal protein L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289491, updated on 2-Nov-2024

Summary

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Symbol
Mrpl1provided by RGD
Full Name
mitochondrial ribosomal protein L1provided by RGD
Primary source
RGD:1306850
See related
EnsemblRapid:ENSRNOG00000002070 AllianceGenome:RGD:1306850
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of large ribosomal subunit. Orthologous to human MRPL1 (mitochondrial ribosomal protein L1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 83.7), Heart (RPKM 82.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl1 in Genome Data Viewer
Location:
14p22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (13604498..13663633, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (13300522..13359654, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14951507..15008136, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene uncharacterized LOC103693729 Neighboring gene uncharacterized LOC120096573 Neighboring gene U2 spliceosomal RNA Neighboring gene CCR4-NOT transcription complex, subunit 6-like Neighboring gene C-X-C motif chemokine ligand 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL1m
Names
39S ribosomal protein L1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105997.2 → NP_001099467.1  large ribosomal subunit protein uL1m

    See identical proteins and their annotated locations for NP_001099467.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168772
    UniProtKB/TrEMBL
    B5DER4, F1M9A4
    Related
    ENSRNOP00000002834.8, ENSRNOT00000002834.8
    Conserved Domains (1) summary
    TIGR01170
    Location:99 → 241
    rplA_mito; ribosomal protein uL1, mitochondrial

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    13604498..13663633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091672.2 → XP_038947600.1  large ribosomal subunit protein uL1m isoform X2

    Conserved Domains (1) summary
    cl00322
    Location:20 → 162
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

  2. XM_039091670.2 → XP_038947598.1  large ribosomal subunit protein uL1m isoform X1

    UniProtKB/TrEMBL
    D3ZFE9, F1M9A4
    Related
    ENSRNOP00000070016.3, ENSRNOT00000085278.3
    Conserved Domains (1) summary
    TIGR01170
    Location:86 → 228
    rplA_mito; ribosomal protein uL1, mitochondrial

  3. XM_063272899.1 → XP_063128969.1  large ribosomal subunit protein uL1m isoform X3

  4. XM_039091673.2 → XP_038947601.1  large ribosomal subunit protein uL1m isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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