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TMEM176B transmembrane protein 176B [ Homo sapiens (human) ]

Gene ID: 28959, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM176Bprovided by HGNC
Official Full Name
transmembrane protein 176Bprovided by HGNC
Primary source
HGNC:HGNC:29596
See related
Ensembl:ENSG00000106565 MIM:610385; AllianceGenome:HGNC:29596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LR8; MS4B2
Summary
Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 288.9), kidney (RPKM 126.6) and 16 other tissues See more
Orthologs
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Genomic context

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Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150791301..150801360, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151964072..151974120, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150488389..150498448, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18783 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene uncharacterized LOC105375566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150496449-150497148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497149-150497848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497849-150498548 Neighboring gene transmembrane protein 176A Neighboring gene uncharacterized LOC105375567 Neighboring gene uncharacterized LOC124901775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150549187-150549758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150553923-150554766 Neighboring gene amine oxidase copper containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The intracellular cation channel TMEM176B as a dual immunoregulator. Hill M, et al. Front Cell Dev Biol, 2022. PMID 36340035, Free PMC Article
  2. The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation. Cambui RAG, et al. J Cancer Res Clin Oncol, 2023 Jul. PMID 35980484
  3. TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury. Picotto G, et al. J Neurotrauma, 2020 Feb 1. PMID 31354034, Free PMC Article
  4. Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology. Cuajungco MP, et al. Acta Histochem, 2012 Nov. PMID 22244448, Free PMC Article
  5. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. Louvet C, et al. Am J Transplant, 2005 Sep. PMID 16095493

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.
    Title: The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.
  2. TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.
    Title: TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.
  3. TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.
    Title: TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.
  4. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus.
    Title: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
  5. human TMEM176A and 176B protein levels are significantly elevated in lymphoma, but not in normal tissues
    Title: Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26014, MGC110857

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 176B
Names
LR8-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101311.2 → NP_001094781.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BI910761
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7, B3KUI8
    Conserved Domains (1) summary
    pfam04103
    Location:66 → 229
    CD20; CD20-like family

  2. NM_001101312.2 → NP_001094782.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7, B3KUI8
    Related
    ENSP00000318409.5, ENST00000326442.10
    Conserved Domains (1) summary
    pfam04103
    Location:66 → 229
    CD20; CD20-like family

  3. NM_001101314.2 → NP_001094784.1  transmembrane protein 176B isoform b

    See identical proteins and their annotated locations for NP_001094784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AK000841, AK129525, BC091471
    Consensus CDS
    CCDS47746.1
    UniProtKB/TrEMBL
    B3KUI8
    Related
    ENSP00000404831.2, ENST00000450753.2
    Conserved Domains (1) summary
    pfam04103
    Location:69 → 192
    CD20; CD20-like family

  4. NM_001362691.2 → NP_001349620.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BI910761, BP370662
    UniProtKB/TrEMBL
    B3KUI8
    Conserved Domains (1) summary
    pfam04103
    Location:82 → 245
    CD20; CD20-like family

  5. NM_001362692.2 → NP_001349621.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BP370662
    UniProtKB/TrEMBL
    B3KUI8
    Conserved Domains (1) summary
    pfam04103
    Location:82 → 245
    CD20; CD20-like family

  6. NM_014020.4 → NP_054739.3  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_054739.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4 encode the same isoform.
    Source sequence(s)
    AK000841, BC004358, BI759037, BP298052
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7, B3KUI8
    Related
    ENSP00000410269.2, ENST00000447204.6
    Conserved Domains (1) summary
    pfam04103
    Location:66 → 229
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150791301..150801360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715933.5 → XP_006715996.2  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006715996.2

    UniProtKB/TrEMBL
    B3KUI8
    Conserved Domains (1) summary
    pfam04103
    Location:69 → 192
    CD20; CD20-like family

  2. XM_047420259.1 → XP_047276215.1  transmembrane protein 176B isoform X2

    UniProtKB/Swiss-Prot
    B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7

  3. XM_047420258.1 → XP_047276214.1  transmembrane protein 176B isoform X3

  4. XM_024446734.2 → XP_024302502.1  transmembrane protein 176B isoform X2

    UniProtKB/Swiss-Prot
    B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7, B3KUI8
    Related
    ENSP00000397810.2, ENST00000429904.6
    Conserved Domains (1) summary
    pfam04103
    Location:66 → 229
    CD20; CD20-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151964072..151974120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357983.1 → XP_054213958.1  transmembrane protein 176B isoform X1

  2. XM_054357985.1 → XP_054213960.1  transmembrane protein 176B isoform X2

  3. XM_054357984.1 → XP_054213959.1  transmembrane protein 176B isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001101313.1: Suppressed sequence

    Description
    NM_001101313.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3YBM2.2 GenPept UniProtKB/Swiss-Prot:Q3YBM2

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