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SLC27A6 solute carrier family 27 member 6 [ Homo sapiens (human) ]

Gene ID: 28965, updated on 2-Nov-2024

Summary

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Official Symbol
SLC27A6provided by HGNC
Official Full Name
solute carrier family 27 member 6provided by HGNC
Primary source
HGNC:HGNC:11000
See related
Ensembl:ENSG00000113396 MIM:604196; AllianceGenome:HGNC:11000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FATP6; ACSVL2; FACVL2; VLCS-H1
Summary
This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 12.7), heart (RPKM 7.8) and 8 other tissues See more
Orthologs
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Genomic context

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See SLC27A6 in Genome Data Viewer
Location:
5q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (128965488..129033635)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (129484343..129552406)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (128301181..128369328)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379167 Neighboring gene uncharacterized LOC105379168 Neighboring gene NANOG hESC enhancer GRCh37_chr5:128006634-128007158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16297 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:128205611-128206165 Neighboring gene MPRA-validated peak5459 silencer Neighboring gene uncharacterized LOC102723638 Neighboring gene uncharacterized LOC124901060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16298 Neighboring gene isochorismatase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in Tumoral and Non-Tumoral Breast Cells. Yen MC, et al. Int J Med Sci, 2019. PMID 30911270, Free PMC Article
  2. A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. Auinger A, et al. Br J Nutr, 2012 May. PMID 21920065
  3. Characterization of a heart-specific fatty acid transport protein. Gimeno RE, et al. J Biol Chem, 2003 May 2. PMID 12556534
  4. Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the Proliferation of Papillary Thyroid Cancer by Regulating c-MYC. Liu C, et al. Biochem Genet, 2022 Dec. PMID 35348939
  5. Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein. Watkins PA, et al. Prostaglandins Leukot Essent Fatty Acids, 1999 May-Jun. PMID 10471116

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the Proliferation of Papillary Thyroid Cancer by Regulating c-MYC.
    Title: Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the Proliferation of Papillary Thyroid Cancer by Regulating c-MYC.
  2. Inverse correlation between SLC27A6 expression and breast tumoral tissues.SLC27A6role in the cell growth and cell cycle regulation in non-tumorigenic breast cells.
    Title: New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in Tumoral and Non-Tumoral Breast Cells.
  3. The FATP6-7T>A polymorphism may protect from traits of the metabolic syndrome and CVD.
    Title: A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
  5. FATP6 is involved in heart LCFA uptake, in which it may play a role in the pathogenesis of lipid-related cardiac disorders.
    Title: Characterization of a heart-specific fatty acid transport protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp779M0564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oleate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid transport TAS
Traceable Author Statement
more info
  
involved_in very long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain fatty acid transport protein 6
Names
acyl-CoA synthetase very long chain family, member 2
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, very long-chain 2
long-chain-fatty-acid--CoA ligase
solute carrier family 27 (fatty acid transporter), member 6
very long-chain acyl-CoA synthetase homolog 1
NP_001017372.1
NP_001304913.1
NP_054750.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017372.3 → NP_001017372.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_001017372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AL833117, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
    UniProtKB/TrEMBL
    B2R8P6
    Related
    ENSP00000262462.4, ENST00000262462.9
    Conserved Domains (2) summary
    cd05938
    Location:77 → 609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16 → 619
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  2. NM_001317984.2 → NP_001304913.1  long-chain fatty acid transport protein 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AK313456, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
    UniProtKB/TrEMBL
    B2R8P6
    Related
    ENSP00000421024.1, ENST00000506176.1
    Conserved Domains (2) summary
    cd05938
    Location:77 → 609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16 → 619
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  3. NM_014031.5 → NP_054750.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_054750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AA614135, AC004636, AF064254, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
    UniProtKB/TrEMBL
    B2R8P6
    Related
    ENSP00000378684.1, ENST00000395266.5
    Conserved Domains (2) summary
    cd05938
    Location:77 → 609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16 → 619
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    128965488..129033635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    129484343..129552406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2P4.1 GenPept UniProtKB/Swiss-Prot:Q9Y2P4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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