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Morc2 MORC family CW-type zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289736, updated on 2-Nov-2024

Summary

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Official Symbol
Morc2provided by RGD
Official Full Name
MORC family CW-type zinc finger 2provided by RGD
Primary source
RGD:1310842
See related
EnsemblRapid:ENSRNOG00000019624 AllianceGenome:RGD:1310842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Morc2a; Zcwcc1
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in DNA damage response and regulation of macromolecule biosynthetic process. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 101.9), Thymus (RPKM 85.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Morc2 in Genome Data Viewer
Location:
14q21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82752444..82794980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78529603..78571375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83889138..83930263)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352784 Neighboring gene taurine up-regulated 1 Neighboring gene taurine up-regulated 1 Neighboring gene oxysterol binding protein 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134481865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Douse CH, et al. Nat Commun, 2018 Feb 13. PMID 29440755, Free PMC Article
  2. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Li DQ, et al. Cell Rep, 2012 Dec 27. PMID 23260667, Free PMC Article
  3. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, et al. Nature, 2018 Jan 11. PMID 29211708, Free PMC Article
  4. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Fukuda K, et al. Genome Res, 2018 Jun. PMID 29728365, Free PMC Article
  5. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Tchasovnikarova IA, et al. Nat Genet, 2017 Jul. PMID 28581500, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase MORC2
Names
MORC family CW-type zinc finger protein 2
microrchidia 2A
zinc finger, CW-type with coiled-coil domain 1
NP_001402037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415108.1 → NP_001402037.1  ATPase MORC2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000069862.3, ENSRNOT00000078980.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    82752444..82794980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005492921.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106016.1: Suppressed sequence

    Description
    NM_001106016.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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