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Ewsr1 EWS RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289752, updated on 2-Nov-2024

Summary

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Symbol
Ewsr1provided by RGD
Full Name
EWS RNA-binding protein 1provided by RGD
Primary source
RGD:1307258
See related
EnsemblRapid:ENSRNOG00000009437 AllianceGenome:RGD:1307258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Cajal body. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 597.9), Spleen (RPKM 406.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ewsr1 in Genome Data Viewer
Location:
14q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84179413..84208149, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79965365..79994108, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85322105..85350826, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Young PJ, et al. Brain Res Mol Brain Res, 2003 Nov 6. PMID 14597228
  2. A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins. Thomsen C, et al. FASEB J, 2013 Dec. PMID 23975937
  3. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Delattre O, et al. Nature, 1992 Sep 10. PMID 1522903
  4. PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Parvanov ED, et al. Mol Biol Cell, 2017 Feb 1. PMID 27932493, Free PMC Article
  5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112874

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein EWS
Names
Ewing sarcoma breakpoint region 1
RNA-binding protein EWS-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025632.3 → NP_001020803.2  RNA-binding protein EWS isoform 2

    See identical proteins and their annotated locations for NP_001020803.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2K850, A0A9K3Y8I9, B1WC50, F1LN98, F1MA60
    Related
    ENSRNOP00000074472.2, ENSRNOT00000086607.3
    Conserved Domains (3) summary
    sd00025
    Location:521 → 542
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:517 → 546
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:360 → 443
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  2. NM_001434406.1 → NP_001421335.1  RNA-binding protein EWS isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84179413..84208149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251203.5 → XP_006251265.2  RNA-binding protein EWS isoform X3

    UniProtKB/TrEMBL
    A0A0G2K850
    Related
    ENSRNOP00000012634.7, ENSRNOT00000012634.8
    Conserved Domains (3) summary
    sd00025
    Location:522 → 543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:518 → 547
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:361 → 444
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  2. XM_006251202.5 → XP_006251264.2  RNA-binding protein EWS isoform X2

    See identical proteins and their annotated locations for XP_006251264.2

    UniProtKB/TrEMBL
    A0A0G2JWK8, A0A140UHY3, A0A8J8Y9N6
    Related
    ENSRNOP00000069920.3, ENSRNOT00000083464.3
    Conserved Domains (4) summary
    PRK12438
    Location:53 → 147
    PRK12438; hypothetical protein; Provisional
    sd00025
    Location:527 → 548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:523 → 552
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:366 → 449
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  3. XM_006251201.5 → XP_006251263.2  RNA-binding protein EWS isoform X1

    See identical proteins and their annotated locations for XP_006251263.2

    UniProtKB/TrEMBL
    A0A8J8Y9N6
    Related
    ENSRNOP00000054193.5, ENSRNOT00000057382.6
    Conserved Domains (4) summary
    PRK12438
    Location:53 → 147
    PRK12438; hypothetical protein; Provisional
    sd00025
    Location:528 → 549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:524 → 553
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:367 → 450
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  4. XM_063272946.1 → XP_063129016.1  RNA-binding protein EWS isoform X4

  5. XM_039091737.2 → XP_038947665.1  RNA-binding protein EWS isoform X6

    UniProtKB/TrEMBL
    Q4KM41
    Conserved Domains (3) summary
    sd00025
    Location:183 → 204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:179 → 208
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd12533
    Location:22 → 105
    RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

  6. XM_063272947.1 → XP_063129017.1  RNA-binding protein EWS isoform X5

  7. XM_008770260.4 → XP_008768482.3  RNA-binding protein EWS isoform X7

    UniProtKB/TrEMBL
    A0A8I6A3F5
    Related
    ENSRNOP00000085477.1, ENSRNOT00000094261.2
Nucleotide Protein Strain
Heading Accession and Version

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