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Rhbdd3 rhomboid domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289753, updated on 2-Nov-2024

Summary

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Official Symbol
Rhbdd3provided by RGD
Official Full Name
rhomboid domain containing 3provided by RGD
Primary source
RGD:1311827
See related
EnsemblRapid:ENSRNOG00000027032 AllianceGenome:RGD:1311827
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311827
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within several processes, including MAPK cascade; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be located in membrane. Orthologous to human RHBDD3 (rhomboid domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 167.0), Adrenal (RPKM 85.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhbdd3 in Genome Data Viewer
Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84208155..84214334)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79994111..80000294)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85350852..85357029)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1 Neighboring gene EWS RNA-binding protein 1 Neighboring gene EMI domain containing 1 Neighboring gene kringle containing transmembrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Liu J, et al. Proc Natl Acad Sci U S A, 2013 May 7. PMID 23610400, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rhomboid domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013875.1 → NP_001013897.1  rhomboid domain-containing protein 3

    See identical proteins and their annotated locations for NP_001013897.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081912
    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Related
    ENSRNOP00000032424.4, ENSRNOT00000031914.7
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84208155..84214334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251207.4 → XP_006251269.1  rhomboid domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006251269.1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  2. XM_063272948.1 → XP_063129018.1  rhomboid domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8

  3. XM_006251205.4 → XP_006251267.1  rhomboid domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006251267.1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  4. XM_006251208.5 → XP_006251270.1  rhomboid domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006251270.1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  5. XM_039091740.2 → XP_038947668.1  rhomboid domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  6. XM_039091738.2 → XP_038947666.1  rhomboid domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  7. XM_006251204.5 → XP_006251266.1  rhomboid domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006251266.1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  8. XM_006251206.5 → XP_006251268.1  rhomboid domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006251268.1

    UniProtKB/Swiss-Prot
    Q642B3
    UniProtKB/TrEMBL
    A6IKK8
    Conserved Domains (1) summary
    cl21463
    Location:326 → 369
    UBA_like_SF; UBA domain-like superfamily

  9. XM_063272949.1 → XP_063129019.1  rhomboid domain-containing protein 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q642B3.1 GenPept UniProtKB/Swiss-Prot:Q642B3

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