U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myl7 myosin light chain 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289759, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Myl7provided by RGD
Official Full Name
myosin light chain 7provided by RGD
Primary source
RGD:1308262
See related
EnsemblRapid:ENSRNOG00000014409 AllianceGenome:RGD:1308262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to be located in A band and dendritic spine. Predicted to be active in myofibril. Orthologous to human MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 9604.7) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Myl7 in Genome Data Viewer
Location:
14q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84994644..84997173, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80780684..80783259, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86144770..86147075, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 2, accessory subunit Neighboring gene uncharacterized LOC108352788 Neighboring gene glucokinase Neighboring gene uncharacterized LOC120096653 Neighboring gene YKT6 v-SNARE homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity. Richard-Bulteau H, et al. Am J Physiol Cell Physiol, 2008 Feb. PMID 18077604
  2. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Grimm M, et al. Cardiovasc Res, 2005 Jan 1. PMID 15621049
  3. An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Nishigaki R, et al. Biochem Biophys Res Commun, 2002 Jul 5. PMID 12083776
  4. Direct interaction of myosin regulatory light chain with the NMDA receptor. Amparan D, et al. J Neurochem, 2005 Jan. PMID 15663482
  5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myosin regulatory light chain 2, atrial isoform
Names
myosin, light chain 7, regulatory
myosin, light polypeptide 7, regulatory

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106017.1 → NP_001099487.1  myosin regulatory light chain 2, atrial isoform

    See identical proteins and their annotated locations for NP_001099487.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473963
    UniProtKB/TrEMBL
    A6IKQ8, B1WC41
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 141
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84994644..84997173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251216.4 → XP_006251278.1  myosin regulatory light chain 2, atrial isoform isoform X1

    UniProtKB/TrEMBL
    B1WC41, F1M7K3
    Related
    ENSRNOP00000019335.6, ENSRNOT00000019335.8
    Conserved Domains (2) summary
    COG5126
    Location:22 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cl08302
    Location:36 → 132
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous