U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fignl1 fidgetin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289777, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Fignl1provided by RGD
Official Full Name
fidgetin-like 1provided by RGD
Primary source
RGD:1307112
See related
EnsemblRapid:ENSRNOG00000004440 AllianceGenome:RGD:1307112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; magnesium ion binding activity; and microtubule severing ATPase activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; osteoblast proliferation; and regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in nuclear chromosome and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 39.2), Thymus (RPKM 30.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fignl1 in Genome Data Viewer
Location:
14q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90573090..90595342, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86368670..86381728, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91895902..91904474, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 1, pseudogene 1 Neighboring gene IKAROS family zinc finger 1 Neighboring gene uncharacterized LOC120096666 Neighboring gene uncharacterized LOC120096667 Neighboring gene dopa decarboxylase Neighboring gene growth factor receptor bound protein 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. mRNA expression analysis of cell cycle genes in islets of pregnant mice. Schraenen A, et al. Diabetologia, 2010 Dec. PMID 20886204, Free PMC Article
  2. Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts. Park SJ, et al. J Bone Miner Res, 2007 Jun. PMID 17352653
  3. Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. Yu Y, et al. Hum Mol Genet, 2006 Jul 15. PMID 16740595
  4. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678, Free PMC Article
  5. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Iwanaga R, et al. Oncogene, 2006 Mar 16. PMID 16288221

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fidgetin-like protein 1
NP_001011913.1
NP_001380737.1
NP_001380738.1
XP_006251539.1
XP_063129023.1
XP_063129024.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011913.2 → NP_001011913.1  fidgetin-like protein 1

    See identical proteins and their annotated locations for NP_001011913.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q6GX84
    UniProtKB/TrEMBL
    A6KJB2
    Conserved Domains (3) summary
    pfam09336
    Location:634 → 674
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:593 → 624
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:383 → 568
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  2. NM_001393808.1 → NP_001380737.1  fidgetin-like protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q6GX84
    UniProtKB/TrEMBL
    A6KJB2
    Conserved Domains (3) summary
    pfam09336
    Location:634 → 674
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:593 → 624
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:383 → 568
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  3. NM_001393809.1 → NP_001380738.1  fidgetin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q6GX84
    UniProtKB/TrEMBL
    A6KJB2
    Related
    ENSRNOP00000101365.1, ENSRNOT00000134653.1
    Conserved Domains (3) summary
    pfam09336
    Location:634 → 674
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:593 → 624
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:383 → 568
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    90573090..90595342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272954.1 → XP_063129024.1  fidgetin-like protein 1 isoform X3

  2. XM_006251477.5 → XP_006251539.1  fidgetin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006251539.1

    UniProtKB/Swiss-Prot
    Q6GX84
    UniProtKB/TrEMBL
    A6KJB2
    Related
    ENSRNOP00000078689.1, ENSRNOT00000107994.2
    Conserved Domains (3) summary
    pfam09336
    Location:634 → 674
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:593 → 624
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:383 → 568
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  3. XM_063272953.1 → XP_063129023.1  fidgetin-like protein 1 isoform X2

    Related
    ENSRNOP00000005857.4, ENSRNOT00000005857.6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GX84.1 GenPept UniProtKB/Swiss-Prot:Q6GX84

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous