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GRIK3 glutamate ionotropic receptor kainate type subunit 3 [ Homo sapiens (human) ]

Gene ID: 2899, updated on 18-Sep-2024

Summary

Official Symbol
GRIK3provided by HGNC
Official Full Name
glutamate ionotropic receptor kainate type subunit 3provided by HGNC
Primary source
HGNC:HGNC:4581
See related
Ensembl:ENSG00000163873 MIM:138243; AllianceGenome:HGNC:4581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAA5; GLR7; GLUR7; GluK3; GluR7a
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues See more
Orthologs
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Genomic context

See GRIK3 in Genome Data Viewer
Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36795527..37034515, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36659019..36898269, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (37261128..37500116, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984941 Neighboring gene uncharacterized LOC105378648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37174760-37175544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37195631-37196342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37196343-37197056 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37225396-37225909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37231217-37231718 Neighboring gene uncharacterized LOC124904023 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:37235886-37236485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37306912-37307481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37315505-37316004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37324384-37325242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37389776-37390276 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:37407041-37407936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37424529-37425095 Neighboring gene MPRA-validated peak179 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37497871-37498770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:37498771-37499670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37500245-37500806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37500807-37501367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37503613-37504173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:37508295-37508862 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:37565375-37566574 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7663 Neighboring gene uncharacterized LOC124904027 Neighboring gene MPRA-validated peak180 silencer Neighboring gene microRNA 4255

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
part_of kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, kainate 3
Names
dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
excitatory amino acid receptor 5
gluR-7
glutamate receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011447.1 RefSeqGene

    Range
    4729..243717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000831.4NP_000822.2  glutamate receptor ionotropic, kainate 3 precursor

    See identical proteins and their annotated locations for NP_000822.2

    Status: REVIEWED

    Source sequence(s)
    AC117945, AJ249210, AL355386, AW898512, BG057125, BG818719, BQ446793, DR003075, DT217951, U16127
    Consensus CDS
    CCDS416.1
    UniProtKB/Swiss-Prot
    A9Z1Z8, B1AMS6, Q13003, Q13004, Q16136
    UniProtKB/TrEMBL
    Q96QG5
    Related
    ENSP00000362183.3, ENST00000373091.8
    Conserved Domains (4) summary
    cd06393
    Location:34417
    PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
    cd13723
    Location:433801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily
    pfam00060
    Location:564832
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:55398
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    36795527..37034515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    36659019..36898269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)