U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osgep O-sialoglycoprotein endopeptidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290028, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Osgepprovided by RGD
Official Full Name
O-sialoglycoprotein endopeptidaseprovided by RGD
Primary source
RGD:1308578
See related
EnsemblRapid:ENSRNOG00000009333 AllianceGenome:RGD:1308578
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 156.8), Heart (RPKM 91.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Osgep in Genome Data Viewer
Location:
15p14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26610694..26618113, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24137149..24144568, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27842447..27849866, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene telomerase associated protein 1 Neighboring gene kelch-like family member 33 Neighboring gene U6 spliceosomal RNA Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomic structure of the rat major AP endonuclease gene (Apex) with an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a processed Apex pseudogene (Apexp1). Yao M, et al. Acta Med Okayama, 1999 Dec. PMID 10631378
  2. Structure, promoter analysis and chromosomal assignment of the human APEX gene. Akiyama K, et al. Biochim Biophys Acta, 1994 Sep 13. PMID 8086453
  3. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Wan LC, et al. Nucleic Acids Res, 2017 Jan 25. PMID 27903914, Free PMC Article
  4. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA threonylcarbamoyladenosine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EKC/KEOPS complex IEA
Inferred from Electronic Annotation
more info
  
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
  
part_of EKC/KEOPS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tRNA N6-adenosine threonylcarbamoyltransferase
Names
N6-L-threonylcarbamoyladenine synthase
O-sialoglycoprotease
Prsmg1/Gcpl1
pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1
probable O-sialoglycoprotein endopeptidase
probable tRNA N6-adenosine threonylcarbamoyltransferase
probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
t(6)A synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep
tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
NP_001093980.1
XP_038949034.1
XP_063130171.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100510.1 → NP_001093980.1  tRNA N6-adenosine threonylcarbamoyltransferase

    See identical proteins and their annotated locations for NP_001093980.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158592
    UniProtKB/Swiss-Prot
    B0BMW7, Q9WVS2
    UniProtKB/TrEMBL
    A0A8I6AEB6
    Related
    ENSRNOP00000012789.4, ENSRNOT00000012790.9
    Conserved Domains (1) summary
    PTZ00340
    Location:4 → 335
    PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26610694..26618113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274101.1 → XP_063130171.1  tRNA N6-adenosine threonylcarbamoyltransferase isoform X1

  2. XM_039093106.2 → XP_038949034.1  tRNA N6-adenosine threonylcarbamoyltransferase isoform X1

    Conserved Domains (1) summary
    PTZ00340
    Location:1 → 254
    PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional

RNA

  1. XR_005493700.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVS2.2 GenPept UniProtKB/Swiss-Prot:Q9WVS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools