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Hnrnpc heterogeneous nuclear ribonucleoprotein C [ Rattus norvegicus (Norway rat) ]

Gene ID: 290046, updated on 2-Nov-2024

Summary

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Official Symbol
Hnrnpcprovided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein Cprovided by RGD
Primary source
RGD:1309982
See related
EnsemblRapid:ENSRNOG00000011621 AllianceGenome:RGD:1309982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrpc; hnRNP C
Summary
Enables several functions, including deaminase binding activity; enzyme inhibitor activity; and ribonucleoprotein complex binding activity. Involved in negative regulation of mRNA modification. Located in nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 442.9), Spleen (RPKM 326.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnpc in Genome Data Viewer
Location:
15p14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27253098..27282779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24779593..24809213, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28486605..28517353, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553296 Neighboring gene olfactory receptor family 5 subfamily AU member 1 Neighboring gene RPGR interacting protein 1 Neighboring gene uncharacterized LOC120096964 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene ribosomal protein L9, pseudogene 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of the nucleic acid-binding domain of the rat HnRNP C-type protein. Sharp ZD, et al. Biochim Biophys Acta, 1990 Apr 6. PMID 2088340
  2. Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer. Fay J, et al. J Med Virol, 2009 May. PMID 19319956
  3. Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia. Panchenko MP, et al. Cardiovasc Pathol, 2009 May-Jun. PMID 18508286, Free PMC Article
  4. Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes. Greeve J, et al. Biol Chem, 1998 Aug-Sep. PMID 9792439
  5. The path of RNA through nuclear pores: apparent entry from the sides into specialized pores. Iborra FJ, et al. J Cell Sci, 2000 Jan. PMID 10633080

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114359

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
  
enables N6-methyladenosine-containing RNA reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables deaminase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasmic periphery of the nuclear pore complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pronucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein C
Names
heterogeneous nuclear ribonucleoprotein C (C1/C2)
heterogeneous nuclear ribonucleoproteins C1/C2
hnRNP C protein C-terminal fragment (158 AA)
hnRNP core protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277600.1 → NP_001264529.1  heterogeneous nuclear ribonucleoprotein C isoform 1

    See identical proteins and their annotated locations for NP_001264529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CB582273, JAXUCZ010000015
    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A6KEG3
    Related
    ENSRNOP00000070427.3, ENSRNOT00000090378.3
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  2. NM_001277601.1 → NP_001264530.1  heterogeneous nuclear ribonucleoprotein C isoform 2

    See identical proteins and their annotated locations for NP_001264530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A0A140TAH9
    Related
    ENSRNOP00000057256.5, ENSRNOT00000060514.5
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  3. NM_001277602.1 → NP_001264531.1  heterogeneous nuclear ribonucleoprotein C isoform 3

    See identical proteins and their annotated locations for NP_001264531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses two alternate in-frame splice sites in the coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2K7B3, A0A8I6GAF8, A6KEG2
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    27253098..27282779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093121.2 → XP_038949049.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A0A140TAH9
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  2. XM_039093111.2 → XP_038949039.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A6KEG3
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  3. XM_039093125.2 → XP_038949053.1  heterogeneous nuclear ribonucleoprotein C isoform X6

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A0A0G2JXW4
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  4. XM_063274116.1 → XP_063130186.1  heterogeneous nuclear ribonucleoprotein C isoform X6

    UniProtKB/TrEMBL
    A0A0G2JXW4

  5. XM_039093123.2 → XP_038949051.1  heterogeneous nuclear ribonucleoprotein C isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7B3, A0A8I6GAF8, A6KEG2
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  6. XM_039093119.2 → XP_038949047.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A0A140TAH9
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  7. XM_063274107.1 → XP_063130177.1  heterogeneous nuclear ribonucleoprotein C isoform X3

  8. XM_063274105.1 → XP_063130175.1  heterogeneous nuclear ribonucleoprotein C isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2H2

  9. XM_039093109.2 → XP_038949037.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A6KEG3
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  10. XM_039093113.2 → XP_038949041.1  heterogeneous nuclear ribonucleoprotein C isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2H2, A0A8I6GAF8
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  11. XM_039093122.2 → XP_038949050.1  heterogeneous nuclear ribonucleoprotein C isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7B3, A0A8I6GAF8, A6KEG2
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  12. XM_039093115.2 → XP_038949043.1  heterogeneous nuclear ribonucleoprotein C isoform X3

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  13. XM_063274117.1 → XP_063130187.1  heterogeneous nuclear ribonucleoprotein C isoform X6

    UniProtKB/TrEMBL
    A0A0G2JXW4

  14. XM_039093116.1 → XP_038949044.1  heterogeneous nuclear ribonucleoprotein C isoform X3

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  15. XM_039093114.1 → XP_038949042.1  heterogeneous nuclear ribonucleoprotein C isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2H2, A0A8I6GAF8
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  16. XM_063274115.1 → XP_063130185.1  heterogeneous nuclear ribonucleoprotein C isoform X6

    UniProtKB/TrEMBL
    A0A0G2JXW4

  17. XM_063274113.1 → XP_063130183.1  heterogeneous nuclear ribonucleoprotein C isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7B3, A6KEG2

  18. XM_039093118.1 → XP_038949046.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A0A140TAH9
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  19. XM_063274104.1 → XP_063130174.1  heterogeneous nuclear ribonucleoprotein C isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2H2

  20. XM_039093108.1 → XP_038949036.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A6KEG3
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  21. XM_063274110.1 → XP_063130180.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/TrEMBL
    A0A140TAH9

  22. XM_063274111.1 → XP_063130181.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/TrEMBL
    A0A140TAH9

  23. XM_063274102.1 → XP_063130172.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/TrEMBL
    A6KEG3

  24. XM_063274108.1 → XP_063130178.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/TrEMBL
    A0A140TAH9

  25. XM_063274109.1 → XP_063130179.1  heterogeneous nuclear ribonucleoprotein C isoform X4

    UniProtKB/TrEMBL
    A0A140TAH9

  26. XM_063274106.1 → XP_063130176.1  heterogeneous nuclear ribonucleoprotein C isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2H2

  27. XM_063274103.1 → XP_063130173.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/TrEMBL
    A6KEG3

  28. XM_039093112.2 → XP_038949040.1  heterogeneous nuclear ribonucleoprotein C isoform X1

    UniProtKB/Swiss-Prot
    D4ACR0, G3V9R8, Q4V8K6
    UniProtKB/TrEMBL
    A6KEG3
    Conserved Domains (1) summary
    cd12603
    Location:10 → 93
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

  29. XM_063274114.1 → XP_063130184.1  heterogeneous nuclear ribonucleoprotein C isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7B3, A6KEG2
    Related
    ENSRNOP00000074135.2, ENSRNOT00000086177.3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025633.1: Suppressed sequence

    Description
    NM_001025633.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V9R8.2 GenPept UniProtKB/Swiss-Prot:G3V9R8

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