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Eef1akmt1 EEF1A lysine methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290279, updated on 18-Sep-2024

Summary

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Official Symbol
Eef1akmt1provided by RGD
Official Full Name
EEF1A lysine methyltransferase 1provided by RGD
Primary source
RGD:1306762
See related
EnsemblRapid:ENSRNOG00000009849 AllianceGenome:RGD:1306762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
N6amt2; RGD1306762
Summary
Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 52.9), Thymus (RPKM 50.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1akmt1 in Genome Data Viewer
Location:
15p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (35809842..35826921, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31694284..31711367, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (37813115..37830932, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene interleukin 17D Neighboring gene exportin 4 Neighboring gene large tumor suppressor kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. Hamey JJ, et al. Mol Cell Proteomics, 2016 Jan. PMID 26545399, Free PMC Article
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188401

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-lysine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EEF1A lysine methyltransferase 1
Names
N(6)-adenine-specific DNA methyltransferase 2
N-6 adenine-specific DNA methyltransferase 2 (putative)
eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
protein-lysine N-methyltransferase N6AMT2
NP_001128462.1
NP_001380751.1
XP_038949067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134990.3 → NP_001128462.1  EEF1A lysine methyltransferase 1

    See identical proteins and their annotated locations for NP_001128462.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A096MKD1, B5DEG5, F7FGJ4
    Related
    ENSRNOP00000068470.3, ENSRNOT00000075861.4
    Conserved Domains (1) summary
    pfam10237
    Location:49 → 161
    N6-adenineMlase; Probable N6-adenine methyltransferase

  2. NM_001393822.1 → NP_001380751.1  EEF1A lysine methyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A096MKD1, B5DEG5, F7FGJ4
    Related
    ENSRNOP00000059566.2, ENSRNOT00000064702.5
    Conserved Domains (1) summary
    pfam10237
    Location:49 → 161
    N6-adenineMlase; Probable N6-adenine methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    35809842..35826921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093139.2 → XP_038949067.1  EEF1A lysine methyltransferase 1 isoform X1

    Related
    ENSRNOP00000107908.1, ENSRNOT00000154417.1
    Conserved Domains (1) summary
    pfam10237
    Location:2 → 114
    N6-adenineMlase; Probable N6-adenine methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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