Tdh L-threonine dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tdhprovided by RGD
Official Full Name: L-threonine dehydrogenaseprovided by RGD
Primary source: RGD:1310214
See related: EnsemblRapid:ENSRNOG00000011342 AllianceGenome:RGD:1310214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable L-threonine 3-dehydrogenase activity and identical protein binding activity. Predicted to be involved in threonine catabolic process. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 4.3), Brain (RPKM 3.9) and 9 other tissues See more
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Genomic context

Location:: 15p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (41915766..41929307, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (37739823..37753365, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (46667926..46682752, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-threonine 3-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-threonine 3-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in threonine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within threonine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in threonine catabolic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: L-threonine 3-dehydrogenase, mitochondrial

NP_001099514.1

EC 1.1.1.103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.