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Thoc3 THO complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290519, updated on 2-Nov-2024

Summary

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Official Symbol
Thoc3provided by RGD
Official Full Name
THO complex subunit 3provided by RGD
Primary source
RGD:1311669
See related
EnsemblRapid:ENSRNOG00000000104 AllianceGenome:RGD:1311669
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 171.9), Adrenal (RPKM 116.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thoc3 in Genome Data Viewer
Location:
17p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (10148281..10157472)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (10143184..10152375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10676943..10686134)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482678 Neighboring gene uncharacterized LOC134482679 Neighboring gene MAPK regulated co-repressor interacting protein 1 like 1 Neighboring gene uncharacterized LOC120097924 Neighboring gene long non-coding RNA 012 Neighboring gene complexin 2 Neighboring gene uncharacterized LOC134482680

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Chi B, et al. Nucleic Acids Res, 2013 Jan. PMID 23222130, Free PMC Article
  2. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
  3. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. Boyne JR, et al. PLoS Pathog, 2008 Oct. PMID 18974867, Free PMC Article
  4. Human mRNA export machinery recruited to the 5' end of mRNA. Cheng H, et al. Cell, 2006 Dec 29. PMID 17190602
  5. Recruitment of the human TREX complex to mRNA during splicing. Masuda S, et al. Genes Dev, 2005 Jul 1. PMID 15998806, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 3
Names
THO complex 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106059.1 → NP_001099529.1  THO complex subunit 3

    See identical proteins and their annotated locations for NP_001099529.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474032
    UniProtKB/TrEMBL
    A6KB01, B5DEY5, F7EUM8
    Related
    ENSRNOP00000000116.6, ENSRNOT00000000116.7
    Conserved Domains (2) summary
    cd00200
    Location:49 → 290
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:59 → 97
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    10148281..10157472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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