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Arhgef3 Rho guanine nucleotide exchange factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290541, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgef3provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 3provided by RGD
Primary source
RGD:1310672
See related
EnsemblRapid:ENSRNOG00000014363 AllianceGenome:RGD:1310672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 192.1), Spleen (RPKM 176.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef3 in Genome Data Viewer
Location:
16p16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2308311..2588634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2301573..2581951)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2743714..3026768)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097513 Neighboring gene HESX homeobox 1 Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC102548056 Neighboring gene uncharacterized LOC134482440 Neighboring gene transcription activation suppressor Neighboring gene coiled-coil domain containing 66 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 3
Names
Rho guanine nucleotide exchange factor (GEF) 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106061.1 → NP_001099531.1  rho guanine nucleotide exchange factor 3

    See identical proteins and their annotated locations for NP_001099531.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474067
    UniProtKB/TrEMBL
    A0A8I6GK05, A6KMK9, D4A1J1
    Related
    ENSRNOP00000019511.4, ENSRNOT00000019511.7
    Conserved Domains (2) summary
    cd10572
    Location:315 → 447
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:125 → 301
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    2308311..2588634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600023.3 → XP_017455512.1  rho guanine nucleotide exchange factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYL3, A0A8I6GK05
    Conserved Domains (2) summary
    cd10572
    Location:342 → 474
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:152 → 328
    RhoGEF; RhoGEF domain

  2. XM_006252575.5 → XP_006252637.1  rho guanine nucleotide exchange factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006252637.1

    UniProtKB/TrEMBL
    A0A0G2JYL3, A0A8I6GK05
    Conserved Domains (2) summary
    cd10572
    Location:342 → 474
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:152 → 328
    RhoGEF; RhoGEF domain

  3. XM_006252574.5 → XP_006252636.1  rho guanine nucleotide exchange factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006252636.1

    UniProtKB/TrEMBL
    A0A0G2JYL3, A0A8I6GK05
    Related
    ENSRNOP00000095441.2, ENSRNOT00000101017.2
    Conserved Domains (2) summary
    cd10572
    Location:342 → 474
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:152 → 328
    RhoGEF; RhoGEF domain

  4. XM_006252576.5 → XP_006252638.1  rho guanine nucleotide exchange factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A424, A0A8I6GK05
    Related
    ENSRNOP00000086642.1, ENSRNOT00000096646.2
    Conserved Domains (2) summary
    cd10572
    Location:322 → 454
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:132 → 308
    RhoGEF; RhoGEF domain

  5. XM_017600022.3 → XP_017455511.1  rho guanine nucleotide exchange factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GK05, A0A8I6GMI2
    Related
    ENSRNOP00000097424.1, ENSRNOT00000119297.2
Nucleotide Protein Strain
Heading Accession and Version

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