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Ghitm growth hormone inducible transmembrane protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 290596, updated on 2-Nov-2024

Summary

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Official Symbol
Ghitmprovided by RGD
Official Full Name
growth hormone inducible transmembrane proteinprovided by RGD
Primary source
RGD:1359301
See related
EnsemblRapid:ENSRNOG00000013961 AllianceGenome:RGD:1359301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MICS1
Summary
Predicted to enable calcium channel activity and calcium:proton antiporter activity. Predicted to be involved in inner mitochondrial membrane organization; monoatomic cation transmembrane transport; and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 1462.3), Adrenal (RPKM 1014.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ghitm in Genome Data Viewer
Location:
16p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (12907062..12918149, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (12885551..12897887, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (14370269..14382647, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 15 ligand Neighboring gene cytochrome c, somatic pseudogene Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene KICSTOR subunit 2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, isolation, and cloning of growth hormone (GH)-inducible interscapular brown adipose complementary deoxyribonucleic acid from GH antagonist mice. Li Y, et al. Endocrinology, 2001 Jul. PMID 11416014
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94737

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium export from the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium export from the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium export from the mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in inner mitochondrial membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth hormone-inducible transmembrane protein
Names
mitochondrial morphology and cristae structure 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005908.1 → NP_001005908.1  growth hormone-inducible transmembrane protein

    See identical proteins and their annotated locations for NP_001005908.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083778
    UniProtKB/Swiss-Prot
    Q5XIA8
    UniProtKB/TrEMBL
    A0A8L2Q9B8, A6K9J5
    Conserved Domains (1) summary
    cd10431
    Location:82 → 345
    GHITM; Growth-hormone inducible transmembrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    12907062..12918149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252786.4 → XP_006252848.1  growth hormone-inducible transmembrane protein isoform X1

    See identical proteins and their annotated locations for XP_006252848.1

    UniProtKB/Swiss-Prot
    Q5XIA8
    UniProtKB/TrEMBL
    A0A8L2Q9B8, A6K9J5
    Related
    ENSRNOP00000077387.1, ENSRNOT00000106368.2
    Conserved Domains (1) summary
    cd10431
    Location:82 → 345
    GHITM; Growth-hormone inducible transmembrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIA8.1 GenPept UniProtKB/Swiss-Prot:Q5XIA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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