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Pde4c phosphodiesterase 4C [ Rattus norvegicus (Norway rat) ]

Gene ID: 290646, updated on 10-Jul-2024

Summary

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Official Symbol
Pde4cprovided by RGD
Official Full Name
phosphodiesterase 4Cprovided by RGD
Primary source
RGD:727918
See related
EnsemblRapid:ENSRNOG00000019518 AllianceGenome:RGD:727918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dpde1
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cilium. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 67.9), Heart (RPKM 30.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde4c in Genome Data Viewer
Location:
16p14
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18724703..18745528, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18690727..18711555, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20442305..20466386, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene colon, intestine and stomach enriched 1 Neighboring gene IQ motif containing N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706893
  2. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2546153, Free PMC Article
  3. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, et al. Gene, 1994 Nov 18. PMID 7958996
  4. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, et al. J Biol Chem, 2011 Sep 2. PMID 21724846, Free PMC Article
  5. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Choi YH, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670265, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC188426

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4C
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
cAMP-specific 35-cyclic phosphodiesterase 4C
cAMP-specific phosphodiesterase 4C
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
NP_001263694.1
XP_006252930.1
XP_006252931.1
XP_063131227.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276765.1 → NP_001263694.1  3',5'-cyclic-AMP phosphodiesterase 4C

    See identical proteins and their annotated locations for NP_001263694.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KA06, A6KA07, G3V8J8
    Related
    ENSRNOP00000026457.5, ENSRNOT00000026457.8
    Conserved Domains (1) summary
    pfam00233
    Location:388 → 629
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18724703..18745528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252868.4 → XP_006252930.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X1

    See identical proteins and their annotated locations for XP_006252930.1

    UniProtKB/TrEMBL
    A6KA06, A6KA07, G3V8J8
    Conserved Domains (1) summary
    pfam00233
    Location:388 → 629
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_006252869.5 → XP_006252931.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X2

    UniProtKB/TrEMBL
    A0A8I6AN21
    Related
    ENSRNOP00000096064.2, ENSRNOT00000113780.2
    Conserved Domains (1) summary
    pfam00233
    Location:348 → 589
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_063275157.1 → XP_063131227.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

    UniProtKB/Swiss-Prot
    P14644
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14644.2 GenPept UniProtKB/Swiss-Prot:P14644

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