U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ing2 inhibitor of growth family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290744, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ing2provided by RGD
Official Full Name
inhibitor of growth family, member 2provided by RGD
Primary source
RGD:1307347
See related
EnsemblRapid:ENSRNOG00000013480 AllianceGenome:RGD:1307347
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ing1l
Summary
Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including positive regulation of transforming growth factor beta receptor signaling pathway; seminiferous tubule development; and spermatogenesis. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Orthologous to human ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 40.2), Thymus (RPKM 33.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ing2 in Genome Data Viewer
Location:
16q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51305311..51316177)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44573592..44584180)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47714756..47725836)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551260 Neighboring gene CDKN2A interacting protein Neighboring gene uncharacterized LOC134482502 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7, pseudogene 1 Neighboring gene ERH, mRNA splicing and mitosis factor, pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. Saito M, et al. PLoS One, 2010 Nov 19. PMID 21124965, Free PMC Article
  2. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. Kaadige MR, et al. J Biol Chem, 2006 Sep 29. PMID 16893883
  3. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. Sarker KP, et al. J Biol Chem, 2008 May 9. PMID 18334480, Free PMC Article
  4. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Chattopadhyay C, et al. Nucleic Acids Res, 2004. PMID 15243141, Free PMC Article
  5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in male germ-line stem cell asymmetric division ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of Sin3-type complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inhibitor of growth protein 2
Names
inhibitor of growth family, member 1-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106083.1 → NP_001099553.1  inhibitor of growth protein 2

    See identical proteins and their annotated locations for NP_001099553.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473995
    UniProtKB/TrEMBL
    A6JPL0, B5DEF8, F7F129
    Conserved Domains (3) summary
    COG5034
    Location:29 → 258
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15683
    Location:212 → 260
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:26 → 120
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    51305311..51316177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253131.5 → XP_006253193.1  inhibitor of growth protein 2 isoform X1

    Related
    ENSRNOP00000102164.1, ENSRNOT00000166374.1
    Conserved Domains (2) summary
    cd15683
    Location:249 → 297
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:93 → 157
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. XM_006253133.5 → XP_006253195.1  inhibitor of growth protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006253195.1

    Conserved Domains (2) summary
    cd15683
    Location:185 → 233
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:30 → 93
    ING; Inhibitor of growth proteins N-terminal histone-binding

  3. XM_006253132.5 → XP_006253194.1  inhibitor of growth protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006253194.1

    Conserved Domains (2) summary
    cd15683
    Location:185 → 233
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:30 → 93
    ING; Inhibitor of growth proteins N-terminal histone-binding
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous