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Pdgfrl platelet-derived growth factor receptor-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 290771, updated on 10-Jul-2024

Summary

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Official Symbol
Pdgfrlprovided by RGD
Official Full Name
platelet-derived growth factor receptor-likeprovided by RGD
Primary source
RGD:1308028
See related
EnsemblRapid:ENSRNOG00000010832 AllianceGenome:RGD:1308028
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human PDGFRL (platelet derived growth factor receptor like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 90.6), Heart (RPKM 47.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pdgfrl in Genome Data Viewer
Location:
16q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58051421..58111327, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51347929..51407850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54386269..54450426, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 1 Neighboring gene uncharacterized LOC120097427 Neighboring gene uncharacterized LOC120097428 Neighboring gene elongin B, pseduogene 1 Neighboring gene solute carrier family 7 member 2 Neighboring gene a disintegrin and metallopeptidase domain 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid. Wang HH, et al. J Neuroinflammation, 2010 Nov 24. PMID 21092323, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet-derived growth factor receptor-like protein
Names
PDGFR-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011921.1 → NP_001011921.1  platelet-derived growth factor receptor-like protein precursor

    See identical proteins and their annotated locations for NP_001011921.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086555
    UniProtKB/Swiss-Prot
    Q5RJP7
    UniProtKB/TrEMBL
    A0A8I6A5A7
    Related
    ENSRNOP00000014623.5, ENSRNOT00000014623.7
    Conserved Domains (3) summary
    smart00410
    Location:83 → 143
    IG_like; Immunoglobulin like
    pfam07679
    Location:272 → 373
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:293 → 372
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    58051421..58111327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJP7.1 GenPept UniProtKB/Swiss-Prot:Q5RJP7

Gene LinkOut

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